Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:Q9NR28 DIABLO
| Class:Id | ReferenceGeneProduct:64638 |
|---|---|
| _chainChangeLog | transit peptide:1-55 added on Fri February 6 2015;chain:56-239 added on Fri February 6 2015;transit peptide:1-55 for 64638 removed on Fri August 11 2023;transit peptide:1-21 for 64638 added on Fri August 11 2023;chain:22-239 for 64638 added on Fri August 11 2023 |
| _displayName | UniProt:Q9NR28 DIABLO |
| _timestamp | 2024-11-03 20:18:42 |
| chain | transit peptide:1-21 chain:22-239 chain:56-239 |
| checksum | 70C2AE0DC654D031 |
| comment | FUNCTION Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/BRUCE by inhibiting its binding to caspases (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106).FUNCTION Attenuates the stability and apoptosis-inhibiting activity of XIAP/BIRC4 by promoting XIAP/BIRC4 ubiquitination and degradation through the ubiquitin-proteasome pathway. Also disrupts XIAP/BIRC4 interacting with processed caspase-9 and promotes caspase-3 activation.FUNCTION Defective in the capacity to down-regulate the XIAP/BIRC4 abundance.SUBUNIT Homodimer (PubMed:10972280, PubMed:36758104, PubMed:36758105, PubMed:36758106). Interacts with BIRC2/c-IAP1 (via BIR3 domain) (PubMed:19153467). Interacts with BIRC6/BRUCE; inhibits BIRC6 activity (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Interacts with BIRC7/livin (PubMed:16729033). Interacts with XIAP/BIRC4 (via BIR3 domain) (PubMed:11140637, PubMed:21695558, PubMed:28288130). Interacts with the monomeric and dimeric form of BIRC5/survivin (PubMed:21536684). Interacts with AREL1 (via HECT domain); in the cytoplasm following induction of apoptosis (PubMed:23479728). Interacts with BEX3 (By similarity).INTERACTION Released into the cytosol in a PARL-dependent manner when cells undergo apoptosis.ALTERNATIVE PRODUCTS Ubiquitously expressed with highest expression in testis. Expression is also high in heart, liver, kidney, spleen, prostate and ovary. Low in brain, lung, thymus and peripheral blood leukocytes. Isoform 3 is ubiquitously expressed.DOMAIN The mature N-terminus mediates interaction with XIAP/BIRC4.PTM Ubiquitinated by BIRC7/livin (PubMed:16729033). Ubiquitinated by BIRC6 (PubMed:36758104, PubMed:36758105, PubMed:36758106).PTM The precursor form is proteolytically cleaved by mitochondrial processing peptidase MPP to remove the transit peptide and produce an intermediate form. This is then processed by PARL to produce the mature cleaved form which is released from mitochondria into the cytosol in apoptotic cells.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the Smac/DIABLO protein family. |
| description | recommendedName: fullName evidence="22"Diablo IAP-binding mitochondrial protein alternativeName: fullName evidence="22"Diablo homolog, mitochondrial alternativeName: fullName evidence="22"Direct IAP-binding protein with low pI alternativeName: fullName evidence="18"Second mitochondria-derived activator of caspases shortName evidence="18"SMAC component recommendedName: Diablo IAP-binding mitochondrial protein, cleaved form /component |
| geneName | DIABLO SMAC |
| identifier | Q9NR28 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Apoptosis Cytoplasm Deafness Direct protein sequencing Disease variant Mitochondrion Non-syndromic deafness Proteomics identification Reference proteome Transit peptide Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9841277] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | DIABLO |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8962494] ENSEMBL:ENSG00000184047 DIABLO [Homo sapiens] |
| secondaryIdentifier | DBLOH_HUMAN B2RDQ0 Q6W3F3 Q96LV0 Q9BT11 Q9HAV6 |
| sequenceLength | 239 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:146227] UniProt:Q9NR28-2 DIABLO [Homo sapiens] [ReferenceIsoform:414711] UniProt:Q9NR28-1 DIABLO [Homo sapiens] [ReferenceIsoform:8971880] UniProt:Q9NR28-3 DIABLO [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:64637] DIABLO [mitochondrial intermembrane space] [Homo sapiens] [EntityWithAccessionedSequence:114298] DIABLO [cytosol] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q9NR28 DIABLO (64638)
