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Details on Person UniProt:O15198 SMAD9
| Class:Id | ReferenceGeneProduct:64636 |
|---|---|
| _chainChangeLog | chain:1-467 added on Fri February 6 2015 |
| _displayName | UniProt:O15198 SMAD9 |
| _timestamp | 2026-02-20 22:16:13 |
| chain | chain:1-467 |
| checksum | CFC8F982945BC6DD |
| comment | FUNCTION Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD9 is a receptor-regulated SMAD (R-SMAD).SUBUNIT Interaction with the co-SMAD SMAD4. Interacts with PEBP2-alpha subunit. Interacts with RANBP3L (PubMed:25755279).INTERACTION In the cytoplasm in the absence of ligand. Migration to the nucleus when complexed with SMAD4 (By similarity).ALTERNATIVE PRODUCTS Expressed in heart, brain, placenta, lung, skeletal muscle, prostate, testis, ovary and small intestine. Also expressed in fetal brain, lung and kidney.PTM Phosphorylated on serine by BMP (bone morphogenetic proteins) type 1 receptor kinase.DISEASE The disease may be caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the dwarfin/SMAD family. |
| description | recommendedName: fullName evidence="11"SMAD family member 9 shortName evidence="10"SMAD 9 alternativeName: Madh6 alternativeName: Mothers against decapentaplegic homolog 9 shortName: MAD homolog 9 shortName: Mothers against DPP homolog 9 |
| geneName | SMAD9 MADH6 MADH9 SMAD8 |
| identifier | O15198 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cytoplasm Disease variant DNA-binding Metal-binding Nucleus Phosphoprotein Proteomics identification Reference proteome Transcription Transcription regulation Zinc |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | SMAD9 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8999157] ENSEMBL:ENSG00000120693 SMAD9 [Homo sapiens] |
| secondaryIdentifier | SMAD9_HUMAN A2A2Y6 O14989 Q5TBA1 |
| sequenceLength | 467 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:154061] UniProt:O15198-2 SMAD9 [Homo sapiens] [ReferenceIsoform:401317] UniProt:O15198-1 SMAD9 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:201441] p-S465,S467-SMAD9 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:201474] p-S465,S467-SMAD9 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:201478] SMAD9 [cytosol] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:201430] O-phospho-L-serine at 467 [ModifiedResidue:201438] O-phospho-L-serine at 465 |
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No pathways have been reviewed or authored by UniProt:O15198 SMAD9 (64636)
