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Details on Person UniProt:Q15797 SMAD1

Class:Id	ReferenceGeneProduct:64616
_chainChangeLog	chain:1-465 added on Sat February 7 2015
_displayName	UniProt:Q15797 SMAD1
_timestamp	2026-02-20 22:38:26
chain	chain:1-465
checksum	2DD34B7F434DBC7E
comment	FUNCTION Transcriptional modulator that plays a role in various cellular processes, including embryonic development, cell differentiation, and tissue homeostasis (PubMed:9335504). Upon BMP ligand binding to their receptors at the cell surface, is phosphorylated by activated type I BMP receptors (BMPRIs) and associates with SMAD4 to form a heteromeric complex which translocates into the nucleus acting as transcription factor (PubMed:33667543). In turn, the hetero-trimeric complex recognizes cis-regulatory elements containing Smad Binding Elements (SBEs) to modulate the outcome of the signaling network (PubMed:33667543). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. Positively regulates BMP4-induced expression of odontogenic development regulator MSX1 following IPO7-mediated nuclear import (By similarity).SUBUNIT Found in a complex with SMAD4 and YY1. Interacts with HGS, NANOG and ZCCHC12 (By similarity). Upon C-terminus phosphorylation: forms trimers with another SMAD1 and the co-SMAD SMAD4 (PubMed:21454478, PubMed:33667543). Interacts with PEBP2-alpha subunit, CREB-binding protein (CBP), p300, SMURF1, SMURF2, USP15 and HOXC8. Associates with ZNF423 or ZNF521 in response to BMP2 leading to activate transcription of BMP target genes. Interacts with SKOR1. Interacts (via MH2 domain) with LEMD3. Binding to LEMD3 results in at least a partial reduction of receptor-mediated phosphorylation. Forms a ternary complex with PSMB4 and OAZ1 before PSMB4 is incorporated into the 20S proteasome. Interacts (via MH2 domain) with FAM83G (via MH2 domain); in a SMAD4-independent manner (PubMed:24554596, PubMed:29789297). Interacts with ZC3H3 (By similarity). Interacts with TMEM119 (By similarity). Interacts (via MH1 and MH2 domains) with ZNF8 (By similarity). Interacts with RANBP3L; the interaction increases when SMAD1 is not phosphorylated and mediates SMAD1 nuclear export (PubMed:25755279). Interacts with EGR1; this interaction inhibits SMAD1 dephosphorylation (By similarity). Interacts with SMAD6 (PubMed:33667543). Interacts with YAP1 (PubMed:21685363). Interacts with MTMR4; negatively regulates BMP signaling through SMAD1 dephosphorylation and retention in endosomes (PubMed:23150675).INTERACTION Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with SMAD4 (PubMed:15647271). Co-localizes with LEMD3 at the nucleus inner membrane (PubMed:15647271). Exported from the nucleus to the cytoplasm when dephosphorylated (By similarity).ALTERNATIVE PRODUCTS Ubiquitous. Highest expression seen in the heart and skeletal muscle.DOMAIN The MH2 domain mediates phosphorylation-dependent trimerization through L3 loop binding of phosphoserines in the adjacent subunit.PTM Phosphorylation of the C-terminal SVS motif by BMP type 1 receptor kinase activates SMAD1 by promoting dissociation from the receptor and trimerization with SMAD4. Phosphorylation by ERK2 MAP kinase in response to EGF or HGF prevents SMAD1 nuclear accumulation and transcriptional activity in response to BMP (PubMed:9335504). Dephosphorylation, probably by PPM1A, induces its export from the nucleus to the cytoplasm (By similarity). Dephosphorylation is inhibited by association with EGR1 (By similarity). Phosphorylation by CDK8/9 creates binding sites for YAP1, and subsequent phosphorylation by GSK3 switches off YAP1 binding and adds binding sites for SMURF1 (PubMed:21685363).PTM Ubiquitinated by SMAD-specific E3 ubiquitin ligase SMURF1, leading to its degradation. Monoubiquitinated, leading to prevent DNA-binding. Deubiquitination by USP15 alleviates inhibition and promotes activation of TGF-beta target genes. Dephosphorylation, probably by PPM1A, induces its export from the nucleus to the cytoplasm (By similarity). Phospho-SMAD1 is ubiquitinated by CHIP leading to disruption of the SMAD1-SMAD4 complex (PubMed:21454478).DISEASE SMAD1 variants may be associated with susceptibility to pulmonary hypertension, a disorder characterized by plexiform lesions of proliferating endothelial cells in pulmonary arterioles. The lesions lead to elevated pulmonary arterial pression, right ventricular failure, and death. The disease can occur from infancy throughout life and it has a mean age at onset of 36 years. Penetrance is reduced. Although familial pulmonary hypertension is rare, cases secondary to known etiologies are more common and include those associated with the appetite-suppressant drugs.SIMILARITY Belongs to the dwarfin/SMAD family.
description	recommendedName: fullName evidence="29"SMAD family member 1 shortName evidence="28"SMAD 1 shortName evidence="28"hSMAD1 alternativeName: JV4-1 alternativeName: Mad-related protein 1 alternativeName: Mothers against decapentaplegic homolog 1 shortName: MAD homolog 1 shortName: Mothers against DPP homolog 1 alternativeName: Transforming growth factor-beta-signaling protein 1 shortName: BSP-1
geneName	SMAD1 BSP1 MADH1 MADR1
identifier	Q15797
isSequenceChanged	FALSE
keyword	3D-structure Acetylation Alternative splicing Cytoplasm Direct protein sequencing DNA-binding Metal-binding Nucleus Phosphoprotein Proteomics identification Reference proteome Transcription Transcription regulation Ubl conjugation Zinc
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20
name	SMAD1
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:8988115] ENSEMBL:ENSG00000170365 SMAD1 [Homo sapiens]
secondaryIdentifier	SMAD1_HUMAN A8KAJ0 D3DNZ9 Q16636 Q9UFT8
sequenceLength	465
species	[Species:48887] Homo sapiens
(isoformParent)	[ReferenceIsoform:8974907] UniProt:Q15797-1 SMAD1 [Homo sapiens] [ReferenceIsoform:8974908] UniProt:Q15797-2 SMAD1 [Homo sapiens]
(referenceEntity)	[EntityWithAccessionedSequence:201464] p-S463,S465-SMAD1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:201468] SMAD1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:201483] p-S463,S465-SMAD1 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:206167] SMAD1 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:6782768] Ub-SMAD1 [cytosol] [Homo sapiens]
(referenceSequence)	[ModifiedResidue:201433] O-phospho-L-serine at 465 [ModifiedResidue:201479] O-phospho-L-serine at 463 [GroupModifiedResidue:6782799] ubiquitinylated lysine (polyubiquitin chain [cytosol]) at unknown position
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No pathways have been reviewed or authored by UniProt:Q15797 SMAD1 (64616)