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Details on Person UniProt:P63165 SUMO1
| Class:Id | ReferenceGeneProduct:64580 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Sat February 7 2015;chain:2-97 added on Sat February 7 2015;propeptide:98-101 added on Sat February 7 2015;initiator methionine:1 for 64580 removed on Fri Nov 03 2023;initiator methionine: for 64580 added on Fri Nov 03 2023;initiator methionine: for 64580 removed on Fri Aug 15 2025;initiator methionine:1 for 64580 added on Fri Aug 15 2025 |
| _displayName | UniProt:P63165 SUMO1 |
| _timestamp | 2026-02-20 22:16:35 |
| chain | initiator methionine:1 chain:2-97 propeptide:98-101 |
| checksum | 89BE97D2D054FB33 |
| comment | FUNCTION Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Covalently attached to the voltage-gated potassium channel KCNB1; this modulates the gating characteristics of KCNB1 (PubMed:19223394). Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. May also regulate a network of genes involved in palate development. Covalently attached to ZFHX3 (PubMed:24651376).SUBUNIT Covalently attached to KCNB1; UBE2I increases cross-linking with KCNB1 and PIAS1 decreases cross-links with KCNB1 (PubMed:15931224, PubMed:19223394). Interacts with SAE2, RANBP2, PIAS1 and PIAS2 (PubMed:10961991, PubMed:15608651, PubMed:15660128, PubMed:15931224, PubMed:16204249). Interacts with PRKN (PubMed:16955485). Covalently attached to a number of proteins such as IKFZ1, PML, RANGAP1, HIPK2, SP100, p53, p73-alpha, MDM2, JUN, DNMT3B and TDG (PubMed:10961991, PubMed:15931224, PubMed:15959518, PubMed:17099698). Also interacts with HIF1A, HIPK2, HIPK3, CHD3, EXOSC9, RAD51 and RAD52 (PubMed:10961991, PubMed:12565818). Interacts with USP25 (via ts SIM domain); the interaction weakly sumoylates USP25 (PubMed:18538659). Interacts with SIMC1, CASP8AP2, RNF111 and SOBP (via SIM domains) (PubMed:23086935). Interacts with BHLHE40/DEC1 (PubMed:21829689). Interacts with RWDD3 (PubMed:17956732). Interacts with UBE2I/UBC9 and this interaction is enhanced in the presence of RWDD3 (PubMed:12924945, PubMed:17956732). Interacts with MTA1 (PubMed:21965678). Interacts with SENP2 (PubMed:15296745). Interacts with HINT1 (By similarity). Interacts with TINCR (via SUMO-interacting motif); the interaction increases TINCR protein stability (PubMed:36369429).SUBUNIT (Microbial infection) Interacts with Epstein-barr virus BGLF4.SUBUNIT (Microbial infection) Interacts (via N-terminus) with Tula hantavirus nucleoprotein.SUBUNIT (Microbial infection) Interacts (via N-terminus) with Hantaan hantavirus nucleoprotein.INTERACTION Recruited by BCL11A into the nuclear body (By similarity). In the presence of ZFHX3, sequesterd to nuclear body (NB)-like dots in the nucleus some of which overlap or closely associate with PML body (PubMed:24651376).ALTERNATIVE PRODUCTS Cleavage of precursor form by SENP1 or SENP2 is necessary for function.PTM Polymeric SUMO1 chains undergo polyubiquitination by RNF4.DISEASE The disease is caused by variants affecting the gene represented in this entry. A chromosomal aberration involving SUMO1 is the cause of OFC10. Translocation t(2;8)(q33.1;q24.3). The breakpoint occurred in the SUMO1 gene and resulted in haploinsufficiency confirmed by protein assays.SIMILARITY Belongs to the ubiquitin family. SUMO subfamily.ONLINE INFORMATION SUMO protein entry |
| description | recommendedName: Small ubiquitin-related modifier 1 shortName: SUMO-1 alternativeName: GAP-modifying protein 1 shortName: GMP1 alternativeName: SMT3 homolog 3 alternativeName: Sentrin alternativeName: Ubiquitin-homology domain protein PIC1 alternativeName: Ubiquitin-like protein SMT3C shortName: Smt3C alternativeName: Ubiquitin-like protein UBL1 |
| geneName | SUMO1 SMT3C SMT3H3 UBL1 OK/SW-cl.43 |
| identifier | P63165 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing Cell membrane Chromosomal rearrangement Cytoplasm Host-virus interaction Isopeptide bond Membrane Nucleus Phosphoprotein Proteomics identification Reference proteome Ubl conjugation Ubl conjugation pathway |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | SUMO1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8962446] ENSEMBL:ENSG00000116030 SUMO1 [Homo sapiens] |
| secondaryIdentifier | SUMO1_HUMAN A8MUS8 B2R4I5 P55856 Q6FGG0 Q6NZ62 Q93068 |
| sequenceLength | 101 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8974073] UniProt:P63165-1 SUMO1 [Homo sapiens] [ReferenceIsoform:8974074] UniProt:P63165-2 SUMO1 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:877304] SUMO1 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:2186788] SUMO1(1-97) [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:2990831] SUMO1(2-101) [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:3000400] SUMO1 [nuclear envelope] [Homo sapiens] [EntityWithAccessionedSequence:3730616] UBA2-G97-SUMO1 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:3730622] UBE2I-G97-SUMO1 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:4656941] UBE2I-G97-SUMO1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:8962678] SUMO1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:8962806] SUMO1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9761562] lysyl-G97-SUMO1 [nucleoplasm] [Homo sapiens] |
| (referenceSequence) | [InterChainCrosslinkedResidue:3465539] Inter-chain Crosslink via S-(glycyl)-L-cysteine (Cys-Gly) at 97 and 93 [InterChainCrosslinkedResidue:3465551] Inter-chain Crosslink via S-(glycyl)-L-cysteine (Cys-Gly) at 97 and 173 [InterChainCrosslinkedResidue:3730743] Inter-chain Crosslink via sumoylated lysine at 97 and 509 [GroupModifiedResidue:3900064] sumoylated lysine (monoSUMO1 [nucleoplasm]) at 499 [InterChainCrosslinkedResidue:8865811] Inter-chain Crosslink via sumoylated lysine at 97 and 10 [ModifiedResidue:9761560] glycine amide at 97 |
| (secondReferenceSequence) | [InterChainCrosslinkedResidue:2993752] Inter-chain Crosslink via S-(glycyl)-L-cysteine (Cys-Gly) at 173 and 97 [InterChainCrosslinkedResidue:2993792] Inter-chain Crosslink via S-(glycyl)-L-cysteine (Cys-Gly) at 93 and 97 |
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No pathways have been reviewed or authored by UniProt:P63165 SUMO1 (64580)
