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Details on Person UniProt:O43623 SNAI2
| Class:Id | ReferenceGeneProduct:64558 |
|---|---|
| _chainChangeLog | chain:1-268 added on Fri February 6 2015 |
| _displayName | UniProt:O43623 SNAI2 |
| _timestamp | 2024-11-03 20:07:47 |
| chain | chain:1-268 |
| checksum | 63F068C8E6B275D4 |
| comment | FUNCTION Transcriptional repressor that modulates both activator-dependent and basal transcription. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1-induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells (By similarity). Represses BRCA2 expression by binding to its E2-box-containing silencer and recruiting CTBP1 and HDAC1 in breast cells. In epidermal keratinocytes, binds to the E-box in ITGA3 promoter and represses its transcription. Involved in the regulation of ITGB1 and ITGB4 expression and cell adhesion and proliferation in epidermal keratinocytes. Binds to E-box2 domain of BSG and activates its expression during TGFB1-induced epithelial-mesenchymal transition (EMT) in hepatocytes. Represses E-Cadherin/CDH1 transcription via E-box elements. Involved in osteoblast maturation. Binds to RUNX2 and SOC9 promoters and may act as a positive and negative transcription regulator, respectively, in osteoblasts. Binds to CXCL12 promoter via E-box regions in mesenchymal stem cells and osteoblasts. Plays an essential role in TWIST1-induced EMT and its ability to promote invasion and metastasis.SUBUNIT Interacts (via SNAG domain) with LIMD1 (via LIM domains), WTIP (via LIM domains) and AJUBA (via LIM domains) (By similarity). Interacts (via zinc fingers) with KPNA2, KPNB1, and TNPO1. May interact (via zinc fingers) with IPO7.INTERACTION Observed in discrete foci in interphase nuclei. These nuclear foci do not overlap with the nucleoli, the SP100 and the HP1 heterochromatin or the coiled body, suggesting SNAI2 is associated with active transcription or active splicing regions.TISSUE SPECIFICITY Expressed in most adult human tissues, including spleen, thymus, prostate, testis, ovary, small intestine, colon, heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Not detected in peripheral blood leukocyte. Expressed in the dermis and in all layers of the epidermis, with high levels of expression in the basal layers (at protein level). Expressed in osteoblasts (at protein level). Expressed in mesenchymal stem cells (at protein level). Expressed in breast tumor cells (at protein level).DOMAIN Repression activity depends on the C-terminal DNA-binding zinc fingers and on the N-terminal repression domain.PTM Phosphorylated by GSK3B. Once phosphorylated, it becomes a target for ubiquitination.PTM Ubiquitinated by the SCF(FBXO11) complex; ubiquitination requires previous GSK3B-mediated SNAI2 phosphorylation (PubMed:25827072).DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the snail C2H2-type zinc-finger protein family. |
| description | recommendedName: Zinc finger protein SNAI2 alternativeName: Neural crest transcription factor Slug alternativeName: Protein snail homolog 2 |
| geneName | SNAI2 SLUG SLUGH |
| identifier | O43623 |
| isSequenceChanged | FALSE |
| keyword | Cytoplasm Deafness Developmental protein DNA-binding Metal-binding Nucleus Proteomics identification Reference proteome Repeat Repressor Transcription Transcription regulation Ubl conjugation Waardenburg syndrome Zinc Zinc-finger |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | SNAI2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9000861] ENSEMBL:ENSG00000019549 SNAI2 [Homo sapiens] |
| secondaryIdentifier | SNAI2_HUMAN B2R6P6 Q53FC1 |
| sequenceLength | 268 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:2980898] SNAI2 [nucleoplasm] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:O43623 SNAI2 (64558)
