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Details on Person UniProt:P31639 SLC5A2
| Class:Id | ReferenceGeneProduct:64536 |
|---|---|
| _chainChangeLog | chain:1-672 added on Sat February 7 2015 |
| _displayName | UniProt:P31639 SLC5A2 |
| _timestamp | 2025-02-21 20:14:24 |
| chain | chain:1-672 |
| checksum | 233C65F1601B0337 |
| comment | FUNCTION Electrogenic Na(+)-coupled sugar symporter that actively transports D-glucose at the plasma membrane, with a Na(+) to sugar coupling ratio of 1:1 (PubMed:20980548, PubMed:28592437, PubMed:34880493, PubMed:37217492, PubMed:38057552). Transporter activity is driven by a transmembrane Na(+) electrochemical gradient set by the Na(+)/K(+) pump (PubMed:20980548, PubMed:28592437, PubMed:34880493). Unlike SLC5A1/SGLT1, requires the auxiliary protein PDZK1IP1/MAP17 for full transporter activity (PubMed:37217492). Has a primary role in D-glucose reabsorption from glomerular filtrate across the brush border of the early proximal tubules of the kidney (By similarity).CATALYTIC ACTIVITY D-glucose(out) + Na(+)(out) = D-glucose(in) + Na(+)(in)ACTIVITY REGULATION Enhanced by the interaction with PDZK1IP1/MAP17 (PubMed:37217492). Inhibited by natural product phlorizin and diabetic drugs, including empagliflozin and dapagliflozin, canagliflozin, and sotagliflozin (PubMed:20980548, PubMed:28592437, PubMed:38057552). Empagliflozin is selective for SLC5A2/SGLT2 over SLC5A1/SGLT1 and it inhibits by occupying the sugar-binding site in SLC5A2 (PubMed:34880493).SUBUNIT Forms a heterodimer (via TM13) with PDZK1IP1 (via N-terminal transmembrane helix); this interaction enhances SLC5A2 transporter activity.INTERACTION The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. |
| description | recommendedName: fullName evidence="11 12"Sodium/glucose cotransporter 2 shortName: Na(+)/glucose cotransporter 2 alternativeName: Low affinity sodium-glucose cotransporter alternativeName: Solute carrier family 5 member 2 |
| geneName | SLC5A2 SGLT2 |
| identifier | P31639 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cell membrane Disease variant Disulfide bond Glycoprotein Ion transport Membrane Metal-binding Proteomics identification Reference proteome Sodium Sodium transport Sugar transport Symport Transmembrane Transmembrane helix Transport |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | SLC5A2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8992127] ENSEMBL:ENSG00000140675 SLC5A2 [Homo sapiens] |
| secondaryIdentifier | SC5A2_HUMAN A2RRD2 |
| sequenceLength | 672 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8967170] UniProt:P31639-1 SLC5A2 [Homo sapiens] [ReferenceIsoform:8967171] UniProt:P31639-2 SLC5A2 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:429568] SLC5A2 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:5658186] SLC5A2 R479G [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:5658191] SLC5A2 Q167fs*20 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:5658194] SLC5A2 W440* [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:5658200] SLC5A2 N654S [plasma membrane] [Homo sapiens] |
| (referenceSequence) | [ReplacedResidue:5658174] L-asparagine 654 replaced with L-serine [FragmentReplacedModification:5658185] Replacement of residues 167 to 185 by RRLWAGTSMPPSSRFWASP [ReplacedResidue:5658193] L-arginine 479 replaced with glycine [NonsenseMutation:5658197] Nonsense mutation at L-tryptophan 440 |
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No pathways have been reviewed or authored by UniProt:P31639 SLC5A2 (64536)
