Query author contributions in Reactome
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Details on Person UniProt:P12755 SKI
| Class:Id | ReferenceGeneProduct:64528 |
|---|---|
| _chainChangeLog | chain:1-728 added on Fri February 6 2015 |
| _displayName | UniProt:P12755 SKI |
| _timestamp | 2024-11-03 20:12:06 |
| chain | chain:1-728 |
| checksum | 9B78C4840A28C2DA |
| comment | FUNCTION May play a role in terminal differentiation of skeletal muscle cells but not in the determination of cells to the myogenic lineage. Functions as a repressor of TGF-beta signaling.SUBUNIT Interacts with SMAD2, SMAD3 and SMAD4. Interacts with HIPK2. Part of a complex with HIPK2 and SMAD1/2/3. Interacts with PRDM16 and SMAD3; the interaction with PRDM16 promotes the recruitment SMAD3-HDAC1 complex on the promoter of TGF-beta target genes.INTERACTION Ubiquitinated by ARK2C, promoting proteasomal degradation, leading to enhance the BMP-Smad signaling.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the SKI family. |
| description | recommendedName: Ski oncogene alternativeName: Proto-oncogene c-Ski |
| geneName | SKI |
| identifier | P12755 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Coiled coil Craniosynostosis Disease variant Nucleus Phosphoprotein Proteomics identification Proto-oncogene Reference proteome Repeat Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9841277] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | SKI |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8989820] ENSEMBL:ENSG00000157933 SKI [Homo sapiens] |
| secondaryIdentifier | SKI_HUMAN Q5SYT7 |
| sequenceLength | 728 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:173473] SKI [nucleoplasm] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P12755 SKI (64528)
