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Details on Person UniProt:Q15477 SKIC2
| Class:Id | ReferenceGeneProduct:64526 |
|---|---|
| _chainChangeLog | chain:1-1246 added on Fri February 6 2015 |
| _displayName | UniProt:Q15477 SKIC2 |
| _timestamp | 2026-02-20 22:38:23 |
| chain | chain:1-1246 |
| checksum | 9F00097BA83A4AEC |
| comment | FUNCTION Helicase component of the SKI complex, a multiprotein complex that assists the RNA-degrading exosome during the mRNA decay and quality-control pathways (PubMed:16024656, PubMed:32006463, PubMed:35120588). The SKI complex catalyzes mRNA extraction from 80S ribosomal complexes in the 3'-5' direction and channels mRNA to the cytosolic exosome for degradation (PubMed:32006463, PubMed:35120588). SKI-mediated extraction of mRNA from stalled ribosomes allow binding of the Pelota-HBS1L complex and subsequent ribosome disassembly by ABCE1 for ribosome recycling (PubMed:32006463). In the nucleus, the SKI complex associates with transcriptionally active genes in a manner dependent on PAF1 complex (PAF1C) (PubMed:16024656). May play a role in the non-stop mRNA decay pathway (NSD), which specifically targets and degrades mRNAs that lack a proper stop codon (PubMed:40441874).CATALYTIC ACTIVITY ATP + H2O = ADP + phosphate + H(+)SUBUNIT Component of the SKI complex which consists of SKIC2, SKIC3 and SKIC8 (PubMed:16024656, PubMed:32006463, PubMed:35120588). Interacts with HBS1L isoform 2 (PubMed:28204585). Interacts with ANGEL1 (PubMed:40441874).INTERACTION The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the helicase family. SKI2 subfamily.SEQUENCE CAUTION Truncated N-terminus. |
| description | recommendedName: fullName evidence="16"Superkiller complex protein 2 shortName evidence="15"Ski2 ecNumber evidence="9 11"3.6.4.13 alternativeName: Helicase-like protein shortName: HLP |
| geneName | SKIC2 DDX13 SKI2W SKIV2 SKIV2L W |
| identifier | Q15477 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure ATP-binding Cytoplasm Disease variant Helicase Hydrolase Nucleotide-binding Nucleus Phosphoprotein Proteomics identification Reference proteome RNA-binding |
| modified | [InstanceEdit:84067] Schmidt, EE, 2003-12-18 04:29:09 [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:2455454] Weiser, JD [InstanceEdit:3445779] Weiser, JD [InstanceEdit:4341137] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:8987656] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9715482] Weiser, JD [InstanceEdit:9796772] Weiser, Joel [InstanceEdit:9829221] Weiser, Joel [InstanceEdit:9841277] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | SKIC2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8962502] ENSEMBL:ENSG00000204351 SKIC2 [Homo sapiens] |
| secondaryIdentifier | SKI2_HUMAN O15005 Q12902 Q15476 Q5ST66 |
| sequenceLength | 1246 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:391294] SKIV2L [cytosol] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q15477 SKIC2 (64526)
