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Details on Person UniProt:Q9UQ13 SHOC2
| Class:Id | ReferenceGeneProduct:64440 |
|---|---|
| _chainChangeLog | chain:1-582 added on Fri February 6 2015 |
| _displayName | UniProt:Q9UQ13 SHOC2 |
| _timestamp | 2026-02-20 21:54:00 |
| chain | chain:1-582 |
| checksum | F3F828646642A855 |
| comment | FUNCTION Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates activation of the MAPK pathway (PubMed:10783161, PubMed:16630891, PubMed:25137548, PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670). Acts as a scaffolding protein in the SMP complex (PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670). The SMP complex specifically dephosphorylates the inhibitory phosphorylation at 'Ser-259' of RAF1 kinase, 'Ser-365' of BRAF kinase and 'Ser-214' of ARAF kinase, stimulating their kinase activities (PubMed:10783161, PubMed:16630891, PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670). The SMP complex enhances the dephosphorylation activity and substrate specificity of PP1c (PubMed:35768504, PubMed:36175670).SUBUNIT Component of the SHOC2-MRAS-PP1c (SMP) complex consisting of SHOC2, GTP-bound M-Ras/MRAS and the catalytic subunit of protein phosphatase 1 (either PPP1CA, PPP1CB or PPP1CC) (PubMed:16630891, PubMed:25137548, PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670). SHOC2 and PP1c preferably bind M-Ras/MRAS, but they also bind K-Ras/KRAS, N-Ras/NRAS and H-Ras/HRAS; these interactions are GTP-dependent and both SHOC2 and PP1c are required to form a stable complex (PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670, PubMed:9674433). Interacts with PP1c in the absence of Ras GTPases (PubMed:35768504, PubMed:35831509). Interacts with M-Ras/MRAS and RAF1 (PubMed:16630891, PubMed:25137548). Interacts with ERBIN; disrupts the interaction with RAF1 and Ras, preventing the activation of the Ras signaling pathway (PubMed:16301319). Interacts with LZTR1 (PubMed:30368668).INTERACTION Translocates from cytoplasm to nucleus upon growth factor stimulation.ALTERNATIVE PRODUCTS Contains a N-terminal RVxF motif that is important for interaction with PP1c.DOMAIN PP1c (all isoforms) binds to the concave side of SHOC2, via LRR 2-5, 8-11, and 13-18 (PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670). M-Ras/MRAS binds to the concave side of SHOC2, via LRR 1-10, 12 and 14-16 (PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670).DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the SHOC2 family.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Truncated N-terminus.ONLINE INFORMATION The matchmaker - Issue 121 of September 2010 |
| description | recommendedName: Leucine-rich repeat protein SHOC-2 alternativeName: Protein soc-2 homolog alternativeName: Protein sur-8 homolog |
| geneName | SHOC2 KIAA0862 |
| identifier | Q9UQ13 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cytoplasm Disease variant Leucine-rich repeat Nucleus Proteomics identification Reference proteome Repeat |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | SHOC2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8993314] ENSEMBL:ENSG00000108061 SHOC2 [Homo sapiens] |
| secondaryIdentifier | SHOC2_HUMAN A8K9W8 B3KR23 O76063 Q5VZS8 Q5VZS9 |
| sequenceLength | 582 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8974903] UniProt:Q9UQ13-1 SHOC2 [Homo sapiens] [ReferenceIsoform:8974904] UniProt:Q9UQ13-2 SHOC2 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:9658444] SHOC2 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9660457] SHOC2 S2G [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9660464] SHOC2 Q269_H270delinsHY [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9660486] SHOC2 M173I [cytosol] [Homo sapiens] |
| (referenceSequence) | [ReplacedResidue:9660461] L-serine 2 replaced with glycine [FragmentReplacedModification:9660465] Replacement of residues 269 to 270 by HY [ReplacedResidue:9660482] L-methionine 173 replaced with L-isoleucine |
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No pathways have been reviewed or authored by UniProt:Q9UQ13 SHOC2 (64440)
