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Details on Person UniProt:Q99962 SH3GL2
| Class:Id | ReferenceGeneProduct:64416 |
|---|---|
| _chainChangeLog | chain:1-352 added on Sat February 7 2015 |
| _displayName | UniProt:Q99962 SH3GL2 |
| _timestamp | 2024-11-03 20:03:14 |
| chain | chain:1-352 |
| checksum | F3AE2353E1EB7CF3 |
| comment | FUNCTION Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature. Required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 to mediate BDNF-NTRK2 early endocytic trafficking and signaling from early endosomes.SUBUNIT Monomer; in cytoplasm. Homodimer; when associated with membranes (By similarity). Interacts with OPHN1 (By similarity). Interacts with SYNJ1 (PubMed:10542231). Interacts with DNM1 (By similarity). Interacts with MAP4K3; the interaction appears to regulate MAP4K3-mediated JNK activation (By similarity). Interacts with PDCD6IP (PubMed:17350572). Interacts with ATXN2 (PubMed:18602463). Interacts with ADAM9 and ADAM15 cytoplasmic tails (PubMed:10531379). Interacts with BIN2 (PubMed:23285027). Interacts with TMEM108 (By similarity). Interacts with ADGRB2 (PubMed:28891236).INTERACTION Brain, mostly in frontal cortex. Expressed at high level in fetal cerebellum.DOMAIN An N-terminal amphipathic helix, the BAR domain and a second amphipathic helix inserted into helix 1 of the BAR domain (N-BAR domain) induce membrane curvature and bind curved membranes. The BAR domain dimer forms a rigid crescent shaped bundle of helices with the pair of second amphipathic helices protruding towards the membrane-binding surface.MISCELLANEOUS HeLa cells expressing the N-BAR domain of SH3GL2 show tubulation of the plasma membrane. The N-BAR domain binds liposomes and induces formation of tubules from liposomes. The N-terminal amphipathic helix is required for liposome binding. The second amphipathic helix enhances liposome tubulation.SIMILARITY Belongs to the endophilin family. |
| description | recommendedName: Endophilin-A1 alternativeName: EEN-B1 alternativeName: Endophilin-1 alternativeName: SH3 domain protein 2A alternativeName: SH3 domain-containing GRB2-like protein 2 |
| geneName | SH3GL2 CNSA2 SH3D2A |
| identifier | Q99962 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Cell projection Coiled coil Cytoplasm Endocytosis Endosome Lipid-binding Membrane Phosphoprotein Proteomics identification Reference proteome SH3 domain Synapse |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | SH3GL2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9004393] ENSEMBL:ENSG00000107295 SH3GL2 [Homo sapiens] |
| secondaryIdentifier | SH3G2_HUMAN B2R618 Q9NQK5 |
| sequenceLength | 352 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:177495] SH3GL2 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:182958] SH3GL2 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:351189] SH3GL2 [Golgi membrane] [Homo sapiens] [EntityWithAccessionedSequence:2130629] SH3GL2 [clathrin-coated endocytic vesicle membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q99962 SH3GL2 (64416)
