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Details on Person UniProt:Q16629 SRSF7
| Class:Id | ReferenceGeneProduct:64368 |
|---|---|
| _chainChangeLog | chain:1-238 added on Sat February 7 2015 |
| _displayName | UniProt:Q16629 SRSF7 |
| _timestamp | 2024-11-03 20:21:38 |
| chain | chain:1-238 |
| checksum | 49136754D9630853 |
| comment | FUNCTION Required for pre-mRNA splicing. Can also modulate alternative splicing in vitro. Represses the splicing of MAPT/Tau exon 10. May function as export adapter involved in mRNA nuclear export such as of histone H2A. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity. RNA-binding is semi-sequence specific.SUBUNIT Found in large molecular weight complexes containing CCNL1 and the p110 isoforms of either CDC2L1 or CDC2L2 (PubMed:12501247, PubMed:14684736). Interacts with CCNL2 and CPSF6 (PubMed:12501247, PubMed:15169763). Interacts with NXF1 (PubMed:12667464, PubMed:17036044). Interacts with YTHDC1 (By similarity).INTERACTION Isoforms, often lacking the RS domain and differentially expressed in fetal tissues, may be involved in modulation of 9G8 function.TISSUE SPECIFICITY Brain, liver, kidney and lung.PTM Extensively phosphorylated on serine residues in the RS domain.SIMILARITY Belongs to the splicing factor SR family. |
| description | recommendedName: Serine/arginine-rich splicing factor 7 alternativeName: Splicing factor 9G8 alternativeName: Splicing factor, arginine/serine-rich 7 |
| geneName | SRSF7 SFRS7 |
| identifier | Q16629 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing Cytoplasm Direct protein sequencing Isopeptide bond Metal-binding mRNA processing mRNA splicing mRNA transport Nucleus Phosphoprotein Proteomics identification Reference proteome Repeat Repressor RNA-binding Transport Ubl conjugation Zinc Zinc-finger |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | SRSF7 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8990428] ENSEMBL:ENSG00000115875 SRSF7 [Homo sapiens] |
| secondaryIdentifier | SRSF7_HUMAN B4DLU6 G5E9M3 Q564D3 |
| sequenceLength | 238 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:153774] UniProt:Q16629-2 SRSF7 [Homo sapiens] [ReferenceIsoform:153775] UniProt:Q16629-3 SRSF7 [Homo sapiens] [ReferenceIsoform:405924] UniProt:Q16629-1 SRSF7 [Homo sapiens] [ReferenceIsoform:8976785] UniProt:Q16629-4 SRSF7 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:72029] SRSF7 [nucleoplasm] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q16629 SRSF7 (64368)
