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Details on Person UniProt:Q9NQR1 KMT5A

Class:Id	ReferenceGeneProduct:64346
_chainChangeLog	chain:1-393 added on Fri February 6 2015
_displayName	UniProt:Q9NQR1 KMT5A
_timestamp	2025-02-21 18:38:07
chain	chain:1-393
checksum	2DCD9B697834B5BD
comment	FUNCTION Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins (PubMed:12086618, PubMed:12121615, PubMed:15964846, PubMed:17707234, PubMed:27338793). Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1) (PubMed:12086618, PubMed:12121615, PubMed:15200950, PubMed:15933069, PubMed:15933070, PubMed:15964846, PubMed:16517599, PubMed:27338793). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression (PubMed:12086618, PubMed:12121615, PubMed:15200950, PubMed:15933069, PubMed:15933070, PubMed:15964846, PubMed:16517599). Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes (PubMed:12086618, PubMed:12121615, PubMed:15200950, PubMed:15933069, PubMed:15933070, PubMed:15964846, PubMed:16517599). Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis (PubMed:12086618, PubMed:12121615, PubMed:15200950, PubMed:15933069, PubMed:15933070, PubMed:15964846, PubMed:16517599). Involved in chromosome condensation and proper cytokinesis (PubMed:12086618, PubMed:12121615, PubMed:15200950, PubMed:15933069, PubMed:15933070, PubMed:15964846, PubMed:16517599). Nucleosomes are preferred as substrate compared to free histones (PubMed:12086618, PubMed:12121615, PubMed:15200950, PubMed:15933069, PubMed:15933070, PubMed:15964846, PubMed:16517599). Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes (PubMed:17707234). Plays a negative role in TGF-beta response regulation and a positive role in cell migration (PubMed:23478445).CATALYTIC ACTIVITY L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine + H(+)CATALYTIC ACTIVITY L-lysyl-[protein] + S-adenosyl-L-methionine = N(6)-methyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine + H(+)SUBUNIT Interacts with L3MBTL1.SUBUNIT Interacts with SIRT2 (phosphorylated form); the interaction is direct, stimulates KMT5A-mediated methyltransferase activity at histone H4 'Lys-20' (H4K20me1) and is increased in a H(2)O(2)-induced oxidative stress-dependent manner.INTERACTION Specifically localizes to mitotic chromosomes (PubMed:12208845). Colocalized with SIRT2 at mitotic foci (PubMed:23468428). Associates with chromosomes during mitosis; association is increased in a H(2)O(2)-induced oxidative stress-dependent manner (PubMed:23468428). Associates with silent chromatin on euchromatic arms (PubMed:12086618). Not associated with constitutive heterochromatin (PubMed:12086618).ALTERNATIVE PRODUCTS Not detected during G1 phase. First detected during S through G2 phases, and peaks during mitosis (at protein level).INDUCTION By HCFC1 C-terminal chain, independently of HCFC1 N-terminal chain. Transiently induced by TGF-beta and during the cell cycle.DOMAIN Although the SET domain contains the active site of enzymatic activity, both sequences upstream and downstream of the SET domain are required for methyltransferase activity.PTM Acetylated at Lys-162; does not affect methyltransferase activity. Deacetylated at Lys-162 possibly by SIRT2; does not change methyltransferase activity.PTM Ubiquitinated and degraded by the DCX(DTL) complex.SIMILARITY Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. PR/SET subfamily.CAUTION It is uncertain whether Met-1 or Met-72 is the initiator.SEQUENCE CAUTION Truncated N-terminus.
description	recommendedName: fullName evidence="23"N-lysine methyltransferase KMT5A ecNumber evidence="24"2.1.1.- alternativeName: H4-K20-HMTase KMT5A alternativeName: Histone-lysine N-methyltransferase KMT5A ecNumber evidence="5 6 11 18"2.1.1.361 alternativeName: Lysine N-methyltransferase 5A alternativeName: fullName evidence="26"Lysine-specific methylase 5A alternativeName: PR/SET domain-containing protein 07 shortName evidence="22"PR-Set7 shortName: PR/SET07 alternativeName: SET domain-containing protein 8
geneName	KMT5A PRSET7 SET07 SET8 SETD8
identifier	Q9NQR1
isSequenceChanged	FALSE
keyword	3D-structure Acetylation Alternative splicing Cell cycle Cell division Chromatin regulator Chromosome Coiled coil Direct protein sequencing Methyltransferase Mitosis Nucleus Phosphoprotein Proteomics identification Reference proteome Repressor S-adenosyl-L-methionine Transcription Transcription regulation Transferase Ubl conjugation
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
name	KMT5A
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:8990214] ENSEMBL:ENSG00000183955 KMT5A [Homo sapiens]
secondaryIdentifier	KMT5A_HUMAN A8K9D0 Q86W83 Q8TD09
sequenceLength	393
species	[Species:48887] Homo sapiens
(isoformParent)	[ReferenceIsoform:153732] UniProt:Q9NQR1-2 KMT5A [Homo sapiens] [ReferenceIsoform:414689] UniProt:Q9NQR1-1 KMT5A [Homo sapiens]
(referenceEntity)	[EntityWithAccessionedSequence:417142] SETD8 [nucleoplasm] [Homo sapiens]
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No pathways have been reviewed or authored by UniProt:Q9NQR1 KMT5A (64346)