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Details on Person UniProt:P78330 PSPH
| Class:Id | ReferenceGeneProduct:64334 |
|---|---|
| _chainChangeLog | chain:1-225 added on Fri February 6 2015 |
| _displayName | UniProt:P78330 PSPH |
| _timestamp | 2025-02-21 19:12:28 |
| chain | chain:1-225 |
| checksum | BD5D72697747FA30 |
| comment | FUNCTION Catalyzes the last irreversible step in the biosynthesis of L-serine from carbohydrates, the dephosphorylation of O-phospho-L-serine to L-serine (PubMed:12213811, PubMed:14673469, PubMed:15291819, PubMed:25080166, PubMed:9222972). L-serine can then be used in protein synthesis, to produce other amino acids, in nucleotide metabolism or in glutathione synthesis, or can be racemized to D-serine, a neuromodulator (PubMed:14673469). May also act on O-phospho-D-serine (Probable).CATALYTIC ACTIVITY O-phospho-L-serine + H2O = L-serine + phosphateCATALYTIC ACTIVITY O-phospho-D-serine + H2O = D-serine + phosphateCOFACTOR Binds 1 Mg(2+) ion per subunit.ACTIVITY REGULATION Inhibited by calcium ions.PATHWAY Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 3/3.SUBUNIT Homodimer.INTERACTION The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the HAD-like hydrolase superfamily. SerB family. |
| description | recommendedName: fullName evidence="12"Phosphoserine phosphatase shortName evidence="12"PSP shortName: PSPase ecNumber evidence="1 3 4 5 6 8"3.1.3.3 alternativeName: fullName evidence="10"L-3-phosphoserine phosphatase alternativeName: O-phosphoserine phosphohydrolase |
| geneName | PSPH |
| identifier | P78330 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Amino-acid biosynthesis Cytoplasm Disease variant Hydrolase Magnesium Metal-binding Proteomics identification Reference proteome Serine biosynthesis |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | PSPH |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9002637] ENSEMBL:ENSG00000146733 PSPH [Homo sapiens] |
| secondaryIdentifier | SERB_HUMAN B2RCR5 Q7Z3S5 |
| sequenceLength | 225 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:977331] PSPH [cytosol] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P78330 PSPH (64334)
