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Details on Person UniProt:P31431 SDC4
Class:Id
ReferenceGeneProduct:64234
_chainChangeLog
signal peptide:1-18 added on Sat February 7 2015;chain:19-198 added on Sat February 7 2015
_displayName
UniProt:P31431 SDC4
_timestamp
2024-11-03 20:07:39
chain
signal peptide:1-18 chain:19-198
checksum
8229AA2733F77A10
comment
FUNCTION Cell surface proteoglycan which regulates exosome biogenesis in concert with SDCBP and PDCD6IP (PubMed:22660413).SUBUNIT Homodimer. Interacts (via its cytoplasmic domain) with GIPC (via its PDZ domain). Interacts (via its cytoplasmic domain) with NUDT16L1 (By similarity). Interacts with CDCP1 and SDCBP (PubMed:12842047, PubMed:16007225, PubMed:16533050). Interacts with DNM2; this interaction is markedly enhanced at focal ahesion site upon induction of focal adhesions and stress-fiber formation (By similarity).INTERACTION Shedding of the ectodomain produces a soluble form.SUBCELLULAR LOCATION Detected in fibroblasts (at protein level) (PubMed:1500433, PubMed:36213313). Also expressed in epithelial cells (PubMed:1500433).PTM Shedding is enhanced by a number of factors such as heparanase, thrombin or EGF. Also by stress and wound healing. PMA-mediated shedding is inhibited by TIMP3.PTM O-glycosylated; contains both chondroitin sulfate and heparan sulfate. Ser-39, Ser-61 and Ser-63 can all be modified by either chondroitin sulfate or heparan sulfate, and the protein exists in forms that contain only chondroitin sulfate, only heparan sulfate and both chondroitin sulfate and heparan sulfate.MISCELLANEOUS Soluble form, lacks the transmembrane domain.SIMILARITY Belongs to the syndecan proteoglycan family.
