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Details on Person UniProt:O75056 SDC3

Class:Id	ReferenceGeneProduct:64232
_chainChangeLog	chain:1-442 added on Sat February 7 2015
_displayName	UniProt:O75056 SDC3
_timestamp	2024-11-03 20:07:39
chain	chain:1-442
checksum	D4C284CBC36A92E2
comment	FUNCTION Cell surface proteoglycan that may bear heparan sulfate (By similarity). May have a role in the organization of cell shape by affecting the actin cytoskeleton, possibly by transferring signals from the cell surface in a sugar-dependent mechanism.SUBUNIT Interacts with TIAM1 (PubMed:23395182). Interacts with PTN (via heparan sulfate chains); this interaction mediates the neurite outgrowth-promoting signal from PTN to the cytoskeleton of growing neurites; this interaction mediates osteoblast recruitment (By similarity). Interacts with MDK; this interaction induces SDC3 clustering; this interaction induces neuronal cell adhesion and neurite outgrowth (By similarity).INTERACTION Expressed in the nervous system, the adrenal gland, and the spleen.PTM O-glycosylated within the Thr/Ser-rich region which could interact with lectin domains on other molecules.SIMILARITY Belongs to the syndecan proteoglycan family.SEQUENCE CAUTION Intron retention.
description	recommendedName: Syndecan-3 shortName: SYND3
geneName	SDC3 KIAA0468
identifier	O75056
isSequenceChanged	FALSE
keyword	Cell membrane Glycoprotein Heparan sulfate Membrane Phosphoprotein Proteoglycan Proteomics identification Reference proteome Transmembrane Transmembrane helix
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
name	SDC3
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:8989805] ENSEMBL:ENSG00000162512 SDC3 [Homo sapiens]
secondaryIdentifier	SDC3_HUMAN Q5T1Z6 Q5T1Z7 Q96CT3 Q96PR8
sequenceLength	442
species	[Species:48887] Homo sapiens
(referenceEntity)	[EntityWithAccessionedSequence:2054110] SDC3 [Golgi lumen] [Homo sapiens] [EntityWithAccessionedSequence:2063983] Gal-Xyl-SDC3 [Golgi lumen] [Homo sapiens] [EntityWithAccessionedSequence:2064042] Gal-Gal-Xyl-SDC3 [Golgi lumen] [Homo sapiens] [EntityWithAccessionedSequence:2064072] XylS-SDC3 [Golgi lumen] [Homo sapiens] [EntityWithAccessionedSequence:2064123] GlcA-Gal-Gal-Xyl-SDC3 [Golgi lumen] [Homo sapiens] [EntityWithAccessionedSequence:2076338] HS(3)-SDC3 [Golgi lumen] [Homo sapiens] [EntityWithAccessionedSequence:2076365] HS(2)-SDC3 [Golgi lumen] [Homo sapiens] [EntityWithAccessionedSequence:2076388] HS(1)-SDC3 [Golgi lumen] [Homo sapiens] [EntityWithAccessionedSequence:2076389] Heparan(3)-SDC3 [Golgi lumen] [Homo sapiens] [EntityWithAccessionedSequence:2076427] Heparan(4)-SDC3 [Golgi lumen] [Homo sapiens] List all 26 refering instances
(referenceSequence)	[GroupModifiedResidue:2063994] O-xylosyl-L-serine (O3-(4-β-D-galactosyl-β-D-xylosyl)-L-serine residue) at unknown position [ModifiedResidue:2064107] O-xylosyl-L-serine at unknown position [GroupModifiedResidue:2064227] O-xylosyl-L-serine (3-O-(β-D-glucuronosyl-(1→3)-β-D-galactosyl-(1→3)-β-D-galactosyl-(1→4)-β-D-xylosyl)-L-serine residue) at unknown position [GroupModifiedResidue:2064252] O-xylosyl-L-serine (O3-(β-D-galactosyl-(1→3)-β-D-galactosyl-(1→4)-β-D-xylosyl)-L-serine residue) at unknown position [GroupModifiedResidue:2076303] O-xylosyl-L-serine (ChEBI:63649) at unknown position [GroupModifiedResidue:2076319] O-xylosyl-L-serine (ChEBI:63657) at unknown position [GroupModifiedResidue:2076380] O-xylosyl-L-serine (ChEBI:63666) at unknown position [GroupModifiedResidue:2076381] O-xylosyl-L-serine (ChEBI:63654) at unknown position [GroupModifiedResidue:2076387] O-xylosyl-L-serine (ChEBI:63661) at unknown position [GroupModifiedResidue:2076441] O-xylosyl-L-serine (ChEBI:63651) at unknown position List all 16 refering instances
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No pathways have been reviewed or authored by UniProt:O75056 SDC3 (64232)