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Details on Person UniProt:Q96T21 SECISBP2
| Class:Id | ReferenceGeneProduct:64166 |
|---|---|
| _chainChangeLog | chain:1-854 added on Fri February 6 2015 |
| _displayName | UniProt:Q96T21 SECISBP2 |
| _timestamp | 2024-11-03 20:03:09 |
| chain | chain:1-854 |
| checksum | A911370853BE4E6E |
| comment | FUNCTION mRNA-binding protein that binds to the SECIS (selenocysteine insertion sequence) element present in the 3'-UTR of mRNAs encoding selenoproteins and facilitates the incorporation of the rare amino acid selenocysteine (PubMed:35709277). Insertion of selenocysteine at UGA codons is mediated by SECISBP2 and EEFSEC: SECISBP2 (1) specifically binds the SECIS sequence once the 80S ribosome encounters an in-frame UGA codon and (2) contacts the RPS27A/eS31 of the 40S ribosome before ribosome stalling (PubMed:35709277). (3) GTP-bound EEFSEC then delivers selenocysteinyl-tRNA(Sec) to the 80S ribosome and adopts a preaccommodated state conformation (PubMed:35709277). (4) After GTP hydrolysis, EEFSEC dissociates from the assembly, selenocysteinyl-tRNA(Sec) accommodates, and peptide bond synthesis and selenoprotein elongation occur (PubMed:35709277).INTERACTION Expressed at high levels in testis.DISEASE The disease is caused by variants affecting the gene represented in this entry.MISCELLANEOUS Contains a transit peptide at positions 1-15. |
| description | recommendedName: fullName evidence="10"Selenocysteine insertion sequence-binding protein 2 shortName evidence="10"SECIS-binding protein 2 |
| geneName | SECISBP2 SBP2 |
| identifier | Q96T21 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Disease variant Mitochondrion Nucleus Protein biosynthesis Proteomics identification Reference proteome RNA-binding Transit peptide |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9909836] Weiser, Joel, 2024-05-14 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | SECISBP2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8995124] ENSEMBL:ENSG00000187742 SECISBP2 [Homo sapiens] |
| secondaryIdentifier | SEBP2_HUMAN F8W892 Q5HYY1 Q7L1Z0 Q8IYC0 Q9H0A1 |
| sequenceLength | 854 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8971193] UniProt:Q96T21-1 SECISBP2 [Homo sapiens] [ReferenceIsoform:8971194] UniProt:Q96T21-2 SECISBP2 [Homo sapiens] [ReferenceIsoform:8971195] UniProt:Q96T21-3 SECISBP2 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:5357715] SECISBP2 [cytosol] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q96T21 SECISBP2 (64166)
