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Details on Person UniProt:Q9UJQ4 SALL4
| Class:Id | ReferenceGeneProduct:64126 |
|---|---|
| _chainChangeLog | chain:1-1053 added on Fri February 6 2015 |
| _displayName | UniProt:Q9UJQ4 SALL4 |
| _timestamp | 2024-11-03 20:21:24 |
| chain | chain:1-1053 |
| checksum | 61D0D1F21CB2B337 |
| comment | FUNCTION Transcription factor with a key role in the maintenance and self-renewal of embryonic and hematopoietic stem cells.SUBUNIT Interacts with POU5F1/OCT4 (PubMed:23012367). Interacts with NANOG (By similarity). Interacts with BEND3 (PubMed:21914818). Interacts with NSD2 (via PHD-type zinc fingers 1, 2 and 3) (By similarity). Interacts with NRBP1 (PubMed:22510880).SUBCELLULAR LOCATION Expressed in testis. Constitutively expressed in acute myeloid leukemia (AML).PTM Isoform SALL4B exists primarily as a ubiquitinated form.PTM Sumoylation with both SUMO1 and SUMO2 regulates the stability, subcellular localization, transcriptional activity, and may reduce interaction with POU5F1/OCT4.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the sal C2H2-type zinc-finger protein family. |
| description | recommendedName: Sal-like protein 4 alternativeName: Zinc finger protein 797 alternativeName: Zinc finger protein SALL4 |
| geneName | SALL4 ZNF797 |
| identifier | Q9UJQ4 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cytoplasm Deafness Disease variant DNA-binding Isopeptide bond Metal-binding Nucleus Oncogene Phosphoprotein Proteomics identification Reference proteome Repeat Transcription Transcription regulation Ubl conjugation Zinc Zinc-finger |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | SALL4 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:2888912] ENSEMBL:ENSG00000101115 SALL4 [Homo sapiens] |
| secondaryIdentifier | SALL4_HUMAN A2A2D8 Q540H3 Q6Y8G6 |
| sequenceLength | 1053 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8971181] UniProt:Q9UJQ4-1 SALL4 [Homo sapiens] [ReferenceIsoform:8971182] UniProt:Q9UJQ4-2 SALL4 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:452644] SALL4 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:3246006] monoSUMO1-4K-SALL4 [nucleoplasm] [Homo sapiens] |
| (referenceSequence) | [GroupModifiedResidue:3246001] sumoylated lysine (monoSUMO1 [nucleoplasm]) at 156 [GroupModifiedResidue:3246068] sumoylated lysine (monoSUMO1 [nucleoplasm]) at 374 [GroupModifiedResidue:3246094] sumoylated lysine (monoSUMO1 [nucleoplasm]) at 838 [GroupModifiedResidue:3246132] sumoylated lysine (monoSUMO1 [nucleoplasm]) at 316 |
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No pathways have been reviewed or authored by UniProt:Q9UJQ4 SALL4 (64126)
