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Details on Person UniProt:Q8N3U4 STAG2
| Class:Id | ReferenceGeneProduct:64100 |
|---|---|
| _chainChangeLog | chain:1-1231 added on Sat February 7 2015 |
| _displayName | UniProt:Q8N3U4 STAG2 |
| _timestamp | 2024-11-03 20:12:15 |
| chain | chain:1-1231 |
| checksum | 692358EFFFF61BB9 |
| comment | FUNCTION Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis.SUBUNIT Interacts directly with RAD21 in cohesin complex. Cohesin complexes are composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein (STAG1, STAG2 or STAG3). In cohesin complexes, STAG2 is mutually exclusive with STAG1 and STAG3.INTERACTION Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK1, except at centromeres, where cohesin complexes remain. At anaphase, the RAD21 subunit of cohesin is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation. In germ cells, cohesin complex dissociates from chromatin at prophase I, and may be replaced by a meiosis-specific cohesin complex.ALTERNATIVE PRODUCTS Phosphorylated by PLK1. The large dissociation of cohesin from chromosome arms during prophase is partly due to its phosphorylation (By similarity).DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the SCC3 family.CAUTION Variants MKMS 743-Trp--Phe-1231 DEL and HPE13 1033-Arg--Phe-1231 DEL were previously described; however, the corresponding paper has been retracted as Case 1's sex was incorrectly reported invalidating the conclusions.SEQUENCE CAUTION Truncated N-terminus. |
| description | recommendedName: Cohesin subunit SA-2 alternativeName: SCC3 homolog 2 alternativeName: Stromal antigen 2 |
| geneName | STAG2 SA2 |
| identifier | Q8N3U4 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing Cell cycle Cell division Centromere Chromosome Chromosome partition Disease variant Holoprosencephaly Meiosis Mitosis Nucleus Phosphoprotein Proteomics identification Reference proteome |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | STAG2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8991579] ENSEMBL:ENSG00000101972 STAG2 [Homo sapiens] |
| secondaryIdentifier | STAG2_HUMAN B1AMT5 D3DTF5 O00540 Q5JTI6 Q68DE9 Q9H1N8 |
| sequenceLength | 1231 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8970300] UniProt:Q8N3U4-1 STAG2 [Homo sapiens] [ReferenceIsoform:8970301] UniProt:Q8N3U4-2 STAG2 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:163046] STAG2 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:163980] p-STAG2 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:1638777] STAG2 [chromosome] [Homo sapiens] [EntityWithAccessionedSequence:1638793] p-STAG2 [chromosome] [Homo sapiens] [EntityWithAccessionedSequence:2466013] p-STAG2 [chromosome, centromeric region] [Homo sapiens] [EntityWithAccessionedSequence:2466018] STAG2 [chromosome, centromeric region] [Homo sapiens] [EntityWithAccessionedSequence:2484806] p-STAG2 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:2484897] STAG2 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:3108187] monoSUMO1-K-STAG2 [nucleoplasm] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:163978] phosphorylated residue at unknown position [GroupModifiedResidue:3108204] sumoylated lysine (monoSUMO1 [nucleoplasm]) at unknown position |
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No pathways have been reviewed or authored by UniProt:Q8N3U4 STAG2 (64100)
