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Details on Person UniProt:Q8WVM7 STAG1
| Class:Id | ReferenceGeneProduct:64098 |
|---|---|
| _chainChangeLog | chain:1-1258 added on Fri February 6 2015 |
| _displayName | UniProt:Q8WVM7 STAG1 |
| _timestamp | 2024-11-03 19:54:09 |
| chain | chain:1-1258 |
| checksum | FAF911998EC52179 |
| comment | FUNCTION Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis.SUBUNIT Cohesin complexes are composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein (STAG1, STAG2 or STAG3) (PubMed:11076961, PubMed:22628566, PubMed:32409525). In cohesin complexes, STAG1 is mutually exclusive with STAG2 and STAG3 (PubMed:11076961). Interacts directly with RAD21 in cohesin complex (By similarity). The cohesin complex interacts with the cohesin loading complex subunits NIPBL/Scc2 (via HEAT repeats) and MAU2/Scc4. NIPBL directly contacts all members of the complex, RAD21, SMC1A/B, SMC3 and STAG1 (PubMed:32409525).INTERACTION Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK1, except at centromeres, where cohesin complexes remain. At anaphase, the RAD21 subunit of cohesin is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation.ALTERNATIVE PRODUCTS Phosphorylated by PLK1. The large dissociation of cohesin from chromosome arms during prophase is partly due to its phosphorylation (By similarity).DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the SCC3 family.ONLINE INFORMATION Support to STAG1 syndrome patients and researchers |
| description | recommendedName: Cohesin subunit SA-1 alternativeName: SCC3 homolog 1 alternativeName: Stromal antigen 1 |
| geneName | STAG1 SA1 SCC3 |
| identifier | Q8WVM7 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cell cycle Cell division Centromere Chromosome Chromosome partition Disease variant Intellectual disability Isopeptide bond Mitosis Nucleus Phosphoprotein Proteomics identification Reference proteome Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | STAG1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8991002] ENSEMBL:ENSG00000118007 STAG1 [Homo sapiens] |
| secondaryIdentifier | STAG1_HUMAN O00539 Q6P275 |
| sequenceLength | 1258 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8966776] UniProt:Q8WVM7-1 STAG1 [Homo sapiens] [ReferenceIsoform:8966777] UniProt:Q8WVM7-2 STAG1 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:163016] STAG1 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:1638773] STAG1 [chromosome] [Homo sapiens] [EntityWithAccessionedSequence:2466017] STAG1 [chromosome, centromeric region] [Homo sapiens] [EntityWithAccessionedSequence:2484793] STAG1 [cytosol] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q8WVM7 STAG1 (64098)
