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Details on Person UniProt:P31213 SRD5A2
| Class:Id | ReferenceGeneProduct:64050 |
|---|---|
| _chainChangeLog | chain:1-254 added on Fri February 6 2015 |
| _displayName | UniProt:P31213 SRD5A2 |
| _timestamp | 2025-02-21 20:14:17 |
| chain | chain:1-254 |
| checksum | 34C9CBD55CF7BCA9 |
| comment | FUNCTION Converts testosterone (T) into 5-alpha-dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.CATALYTIC ACTIVITY a 3-oxo-5alpha-steroid + NADP(+) = a 3-oxo-Delta(4)-steroid + NADPH + H(+)CATALYTIC ACTIVITY 17beta-hydroxy-5alpha-androstan-3-one + NADP(+) = testosterone + NADPH + H(+)CATALYTIC ACTIVITY 5alpha-pregnane-3,20-dione + NADP(+) = progesterone + NADPH + H(+)BIOPHYSICOCHEMICAL PROPERTIES Optimally active at acidic pHs.INTERACTION Expressed in high levels in the prostate and many other androgen-sensitive tissues.POLYMORPHISM Individuals with Thr-49 have an increased risk of prostate cancer (PubMed:10501358). The enzyme with Thr-49 has a higher in vitro V(max) than the Ala-49 enzyme (PubMed:10501358).DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the steroid 5-alpha reductase family.ONLINE INFORMATION 5-alpha reductase entry |
| description | recommendedName: 3-oxo-5-alpha-steroid 4-dehydrogenase 2 ecNumber evidence="4"1.3.1.22 alternativeName: 5 alpha-SR2 alternativeName: SR type 2 alternativeName: Steroid 5-alpha-reductase 2 shortName: S5AR 2 alternativeName: Type II 5-alpha reductase |
| geneName | SRD5A2 |
| identifier | P31213 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Differentiation Disease variant Endoplasmic reticulum Lipid metabolism Membrane Microsome NADP Oxidoreductase Proteomics identification Pseudohermaphroditism Reference proteome Sexual differentiation Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9841277] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | SRD5A2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8996250] ENSEMBL:ENSG00000277893 SRD5A2 [Homo sapiens] |
| secondaryIdentifier | S5A2_HUMAN B2RE87 Q2M1R4 Q9BYE6 |
| sequenceLength | 254 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:469664] SRD5A2 [endoplasmic reticulum membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P31213 SRD5A2 (64050)
