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Details on Person UniProt:O43868 SLC28A2
| Class:Id | ReferenceGeneProduct:64026 |
|---|---|
| _chainChangeLog | chain:1-658 added on Fri February 6 2015 |
| _displayName | UniProt:O43868 SLC28A2 |
| _timestamp | 2025-02-21 19:42:53 |
| chain | chain:1-658 |
| checksum | 273545EE75E0D663 |
| comment | FUNCTION Sodium-dependent and purine-selective transporter (PubMed:10087507, PubMed:9435697). Exhibits the transport characteristics of the nucleoside transport system cif or N1 subtype (N1/cif) (selective for purine nucleosides and uridine) (PubMed:10087507, PubMed:21795683, PubMed:9435697). Plays a critical role in specific uptake and salvage of purine nucleosides in kidney and other tissues (PubMed:9435697). May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (Probable).CATALYTIC ACTIVITY adenosine(out) + Na(+)(out) = adenosine(in) + Na(+)(in)CATALYTIC ACTIVITY inosine(out) + Na(+)(out) = inosine(in) + Na(+)(in)CATALYTIC ACTIVITY guanosine(out) + Na(+)(out) = guanosine(in) + Na(+)(in)CATALYTIC ACTIVITY uridine(out) + Na(+)(out) = uridine(in) + Na(+)(in)ACTIVITY REGULATION Inhibited by formycin B.SUBCELLULAR LOCATION Localized to the apicolateral membranes of Sertoli cells and vascular endothelial cells in testis.TISSUE SPECIFICITY Expressed in heart and skeletal muscle followed by liver, kidney, intestine, pancreas, placenta and brain (PubMed:9435697). Weak expression in lung (PubMed:9435697). In testis, primarily localized to the apicolateral membranes of Sertoli cells and vascular endothelial cells, and weakly expressed in Leydig cells, peritubular myoid cells and germ cells (PubMed:35307651).SIMILARITY Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family. |
| description | recommendedName: Sodium/nucleoside cotransporter 2 alternativeName: Concentrative nucleoside transporter 2 shortName: CNT 2 shortName: hCNT2 alternativeName: Na(+)/nucleoside cotransporter 2 alternativeName: Sodium-coupled nucleoside transporter 2 alternativeName: fullName evidence="10"Sodium/purine nucleoside co-transporter shortName evidence="10"SPNT alternativeName: Solute carrier family 28 member 2 |
| geneName | SLC28A2 CNT2 |
| identifier | O43868 |
| isSequenceChanged | FALSE |
| keyword | Cell membrane Membrane Phosphoprotein Proteomics identification Reference proteome Transmembrane Transmembrane helix Transport |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | SLC28A2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8988094] ENSEMBL:ENSG00000137860 SLC28A2 [Homo sapiens] |
| secondaryIdentifier | S28A2_HUMAN A8K7F9 O43239 Q52LZ0 |
| sequenceLength | 658 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:64025] SLC28A2 [plasma membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:O43868 SLC28A2 (64026)
