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Details on Person UniProt:Q15436 SEC23A
| Class:Id | ReferenceGeneProduct:64008 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-765 added on Fri February 6 2015;initiator methionine:1 for 64008 removed on Fri Nov 03 2023;initiator methionine: for 64008 added on Fri Nov 03 2023;initiator methionine: for 64008 removed on Fri Aug 15 2025;initiator methionine:1 for 64008 added on Fri Aug 15 2025 |
| _displayName | UniProt:Q15436 SEC23A |
| _timestamp | 2025-08-15 21:48:55 |
| chain | initiator methionine:1 chain:2-765 |
| checksum | 128DF9964B253313 |
| comment | FUNCTION Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex. Required for the translocation of insulin-induced glucose transporter SLC2A4/GLUT4 to the cell membrane (By similarity).SUBUNIT COPII is composed of at least five proteins: the Sec23/24 complex, the Sec13/31 complex and Sar1 (PubMed:17499046). Interacts with SEC23IP. Interacts with HTR4 (By similarity). Interacts with SEC16A (PubMed:17192411). Interacts with SLC6A4 (By similarity). Interacts (as part of the Sec23/24 complex) with SEC22B; recruits SEC22B into COPII-coated vesicles and allows the transport of this cargo from the endoplasmic reticulum to the Golgi (PubMed:17499046). Interacts (via Gelsolin-like repeat) with MIA2 and MIA3; specifically involved in the transport of large cargos like the collagen COL7A1 (PubMed:27551091, PubMed:28442536). Interacts with DDHD1 (By similarity). Interacts with TMEM39A (PubMed:31806350). Interacts with SACM1L; this interaction is reduced in the absence of TMEM39A (PubMed:31806350). Interacts with kinase FAM20C; transport of FAM20C from the endoplasmic reticulum to the Golgi is likely to be mediated by COPII vesicles (PubMed:34349020).INTERACTION Enriched at endoplasmic reticulum exit sites, also known as transitional endoplasmic reticulum (tER).ALTERNATIVE PRODUCTS Ubiquitously expressed.DOMAIN The Gelsolin-like repeat mediates interaction with proteins containing PPP motifs that include MIA2, MIA3 but also SEC31A. These interactions are probably competitive.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the SEC23/SEC24 family. SEC23 subfamily. |
| description | recommendedName: fullName evidence="16"Protein transport protein Sec23A shortName evidence="15"hSec23A alternativeName: SEC23-related protein A |
| geneName | SEC23A |
| identifier | Q15436 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing Cytoplasm Cytoplasmic vesicle Disease variant Endoplasmic reticulum ER-Golgi transport Membrane Metal-binding Phosphoprotein Protein transport Proteomics identification Reference proteome Transport Zinc |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | SEC23A |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8988658] ENSEMBL:ENSG00000100934 SEC23A [Homo sapiens] |
| secondaryIdentifier | SC23A_HUMAN B2R5P4 B3KXI2 Q8NE16 |
| sequenceLength | 765 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8972560] UniProt:Q15436-1 SEC23A [Homo sapiens] [ReferenceIsoform:8972561] UniProt:Q15436-2 SEC23A [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:203972] SEC23A [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:203976] SEC23A [endoplasmic reticulum membrane] [Homo sapiens] [EntityWithAccessionedSequence:204024] SEC23A [ER to Golgi transport vesicle membrane] [Homo sapiens] [EntityWithAccessionedSequence:5685740] p-S738,T744 SEC23A [cytosol] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:5685738] O-phospho-L-threonine at 744 [ModifiedResidue:5685741] O-phospho-L-serine at 738 |
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No pathways have been reviewed or authored by UniProt:Q15436 SEC23A (64008)
