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Details on Person UniProt:P48443 RXRG
| Class:Id | ReferenceGeneProduct:63886 |
|---|---|
| _chainChangeLog | chain:1-463 added on Sat February 7 2015 |
| _displayName | UniProt:P48443 RXRG |
| _timestamp | 2024-11-03 20:03:02 |
| chain | chain:1-463 |
| checksum | AED5C94BB62A3157 |
| comment | FUNCTION Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity).SUBUNIT Homodimer (By similarity). Heterodimer with a RAR molecule (PubMed:28167758). Binds DNA preferentially as a RAR/RXR heterodimer (PubMed:28167758). Interacts with RARA (PubMed:28167758).INTERACTION Expressed in aortic endothelial cells (at protein level).DOMAIN Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.PTM Acetylated by EP300.SIMILARITY Belongs to the nuclear hormone receptor family. NR2 subfamily. |
| description | recommendedName: Retinoic acid receptor RXR-gamma alternativeName: Nuclear receptor subfamily 2 group B member 3 alternativeName: Retinoid X receptor gamma |
| geneName | RXRG NR2B3 |
| identifier | P48443 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Cytoplasm DNA-binding Metal-binding Nucleus Proteomics identification Receptor Reference proteome Transcription Transcription regulation Zinc Zinc-finger |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | RXRG |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9000292] ENSEMBL:ENSG00000143171 RXRG [Homo sapiens] |
| secondaryIdentifier | RXRG_HUMAN A6NIP1 Q6IBU7 |
| sequenceLength | 463 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:446170] RXRG [nucleoplasm] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P48443 RXRG (63886)
