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Details on Person UniProt:P17081 RHOQ
| Class:Id | ReferenceGeneProduct:63832 |
|---|---|
| _chainChangeLog | chain:1-202 added on Sat February 7 2015;propeptide:203-205 added on Sat February 7 2015 |
| _displayName | UniProt:P17081 RHOQ |
| _timestamp | 2024-11-03 19:53:39 |
| chain | chain:1-202 propeptide:203-205 |
| checksum | 82695B4F8FBF0B75 |
| comment | FUNCTION Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. May play a role in CFTR trafficking to the plasma membrane. Causes the formation of thin, actin-rich surface projections called filopodia.ACTIVITY REGULATION Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP, GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity, and GDP dissociation inhibitors which inhibit the dissociation of the nucleotide from the GTPase.SUBUNIT Interacts with CDC42EP4 in a GTP-dependent manner. Interacts with ARHGAP33/TCGAP (By similarity). Interacts with CDC42EP1, CDC42EP2, CDC42EP3, PARD6A, PARD6G (and probably PARD6B) in a GTP-dependent manner. Part of a quaternary complex containing PARD3, some PARD6 protein (PARD6A, PARD6B or PARD6G) and some atypical PKC protein (PRKCI or PRKCZ). Interacts with EXO70 in a GTP-dependent manner. Interacts with GOPC.INTERACTION May be post-translationally modified by both palmitoylation and polyisoprenylation.SIMILARITY Belongs to the small GTPase superfamily. Rho family. |
| description | recommendedName: Rho-related GTP-binding protein RhoQ alternativeName: Ras-like protein TC10 alternativeName: Ras-like protein family member 7A |
| geneName | RHOQ ARHQ RASL7A TC10 |
| identifier | P17081 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Cell membrane Cytoplasm GTP-binding Lipoprotein Membrane Methylation Nucleotide-binding Prenylation Proteomics identification Reference proteome |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | RHOQ |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8994464] ENSEMBL:ENSG00000119729 RHOQ [Homo sapiens] |
| secondaryIdentifier | RHOQ_HUMAN D6W5A6 Q0VGN1 Q52LS8 Q53SJ1 Q6NS39 Q6P146 Q7Z480 |
| sequenceLength | 205 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:194856] RHOQ [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:194879] RHOQ [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:5627086] RHOQ [Golgi-associated vesicle membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P17081 RHOQ (63832)
