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Details on Person UniProt:P10826 RARB
| Class:Id | ReferenceGeneProduct:63578 |
|---|---|
| _chainChangeLog | chain:1-455 added on Sat February 7 2015 |
| _displayName | UniProt:P10826 RARB |
| _timestamp | 2026-02-20 21:43:28 |
| chain | chain:1-455 |
| checksum | 8813263AD0495D5A |
| comment | FUNCTION Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence or presence of hormone ligand, acts mainly as an activator of gene expression due to weak binding to corepressors (PubMed:12554770). The RXRA/RARB heterodimer can act as a repressor on the DR1 element and as an activator on the DR5 element (PubMed:29021580). In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function (By similarity).SUBUNIT Homodimer (By similarity). Heterodimer; with a RXR molecule (By similarity). Binds DNA preferentially as a RAR/RXR heterodimer (By similarity). Heterodimerizes (via NR LBD) with RXRA (PubMed:29021580). Interacts weakly with NCOR2 (PubMed:12554770).INTERACTION Expressed in aortic endothelial cells (at protein level).DOMAIN Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.DOMAIN The DNA-binding nuclear receptor domain and the NR LBD domain are required for binding of the RARB/RXRA heterodimer to both DR1 and DR5 DNA elements.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the nuclear hormone receptor family. NR1 subfamily. |
| description | recommendedName: Retinoic acid receptor beta shortName: RAR-beta alternativeName: HBV-activated protein alternativeName: Nuclear receptor subfamily 1 group B member 2 alternativeName: RAR-epsilon |
| geneName | RARB HAP NR1B2 |
| identifier | P10826 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cytoplasm Disease variant DNA-binding Metal-binding Microphthalmia Nucleus Phosphoprotein Proteomics identification Proto-oncogene Receptor Reference proteome Transcription Transcription regulation Zinc Zinc-finger |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | RARB |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8990354] ENSEMBL:ENSG00000077092 RARB [Homo sapiens] |
| secondaryIdentifier | RARB_HUMAN P12891 Q00989 Q15298 Q9UN48 |
| sequenceLength | 455 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:153310] UniProt:P10826-2 RARB [Homo sapiens] [ReferenceIsoform:153311] UniProt:P10826-4 RARB [Homo sapiens] [ReferenceIsoform:153312] UniProt:P10826-3 RARB [Homo sapiens] [ReferenceIsoform:402768] UniProt:P10826-1 RARB [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:446178] RARB [nucleoplasm] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P10826 RARB (63578)
