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Details on Person UniProt:P19388 POLR2E

Class:Id	ReferenceGeneProduct:63511
_chainChangeLog	chain:1-210 added on Fri February 6 2015
_displayName	UniProt:P19388 POLR2E
_timestamp	2024-11-03 19:58:21
chain	chain:1-210
checksum	1E88AFDBCF9C8535
comment	FUNCTION DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2E/RPABC1 is part of the lower jaw surrounding the central large cleft and thought to grab the incoming DNA template.SUBUNIT Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively (PubMed:16809778, PubMed:33335104, PubMed:33558764, PubMed:33558766, PubMed:33674783, PubMed:34675218, PubMed:9852112). Pol I complex consists of a ten-subunit catalytic core composed of POLR1A/RPA1, POLR1B/RPA2, POLR1C/RPAC1, POLR1D/RPAC2, POLR1H/RPA12, POLR2E/RPABC1, POLR2F/RPABC2, POLR2H/RPABC3, POLR2K/RPABC4 and POLR2L/RPABC5; a mobile stalk subunit POLR1F/RPA43 protruding from the core and additional subunits homologous to general transcription factors POLR1E/RPA49 and POLR1G/RPA34. Part of Pol I pre-initiation complex (PIC), in which Pol I core assembles with RRN3 and promoter-bound UTBF and SL1/TIF-IB complex (PubMed:34671025, PubMed:34887565, PubMed:36271492). Pol II complex contains a ten-subunit catalytic core composed of POLR2A/RPB1, POLR2B/RPB2, POLR2C/RPB3, POLR2I/RPB9, POLR2J/RPB11, POLR2E/RPABC1, POLR2F/RPABC2, POLR2H/RPABC3, POLR2K/RPABC4 and POLR2L/RPABC5 and a mobile stalk composed of two subunits POLR2D/RPB4 and POLR2G/RPB7. Part of Pol II(G) complex, in which Pol II core associates with an additional subunit POLR2M; unlike conventional Pol II, Pol II(G) functions as a transcriptional repressor. Part of TBP-based Pol II pre-initiation complex (PIC), in which Pol II core assembles with general transcription factors and other specific initiation factors including GTF2E1, GTF2E2, GTF2F1, GTF2F2, TCEA1, ERCC2, ERCC3, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2A1, GTF2A2, GTF2B and TBP; this large multi-subunit PIC complex mediates DNA unwinding and targets Pol II core to the transcription start site where the first phosphodiester bond forms. In Pol II complex, this subunit is present in 2-fold molar excess over the other subunits (PubMed:27193682, PubMed:30190596, PubMed:9852112). Pol III complex consists of a ten-subunit catalytic core composed of POLR3A/RPC1, POLR3B/RPC2, POLR1C/RPAC1, POLR1D/RPAC2, POLR3K/RPC10, POLR2E/RPABC1, POLR2F/RPABC2, POLR2H/RPABC3, POLR2K/RPABC4 and POLR2L/RPABC5; a mobile stalk composed of two subunits POLR3H/RPC8 and CRCP/RPC9, protruding from the core and functioning primarily in transcription initiation; and additional subunits homologous to general transcription factors of the RNA polymerase II machinery, POLR3C/RPC3-POLR3F/RPC6-POLR3G/RPC7 heterotrimer required for transcription initiation and POLR3D/RPC4-POLR3E/RPC5 heterodimer involved in both transcription initiation and termination (PubMed:33335104, PubMed:33558764, PubMed:33558766, PubMed:33674783, PubMed:34675218). Component of the PAQosome complex which is responsible for the biogenesis of several protein complexes and which consists of R2TP complex members RUVBL1, RUVBL2, RPAP3 and PIH1D1, URI complex members PFDN2, PFDN6, PDRG1, UXT and URI1 as well as ASDURF, POLR2E and DNAAF10/WDR92 (PubMed:31738558). Interacts with URI1 (PubMed:9819440).SUBUNIT (Microbial infection) Interacts with HBV protein X.INTERACTION Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
description	recommendedName: DNA-directed RNA polymerases I, II, and III subunit RPABC1 shortName: RNA polymerases I, II, and III subunit ABC1 alternativeName: DNA-directed RNA polymerase II 23 kDa polypeptide alternativeName: DNA-directed RNA polymerase II subunit E alternativeName: RPB5 homolog alternativeName: XAP4
geneName	POLR2E
identifier	P19388
isSequenceChanged	FALSE
keyword	3D-structure Acetylation Direct protein sequencing DNA-directed RNA polymerase Host-virus interaction Isopeptide bond Nucleus Proteomics identification Reference proteome Transcription Ubl conjugation
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9909836] Weiser, Joel, 2024-05-14 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
name	POLR2E
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:9004941] ENSEMBL:ENSG00000099817 POLR2E [Homo sapiens]
secondaryIdentifier	RPAB1_HUMAN B2R6L4 D6W5Y1 O43380 Q6PIH5 Q9BT06
sequenceLength	210
species	[Species:48887] Homo sapiens
(referenceEntity)	[EntityWithAccessionedSequence:83713] POLR2E [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:1964438] POLR2E [cytosol] [Homo sapiens]
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No pathways have been reviewed or authored by UniProt:P19388 POLR2E (63511)