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Details on Person UniProt:Q9H1E1 RNASE7

Class:IdReferenceGeneProduct:63411
_chainChangeLogsignal peptide:1-28 added on Fri February 6 2015;chain:29-156 added on Fri February 6 2015
_displayNameUniProt:Q9H1E1 RNASE7
_timestamp2024-11-03 20:11:52
chainsignal peptide:1-28
chain:29-156
checksumA8659D3EECEF4054
commentFUNCTION Exhibits a potent RNase activity (PubMed:12244054, PubMed:12527768, PubMed:17150966). Has broad-spectrum antimicrobial activity against many pathogenic microorganisms including uropathogenic E.coli (UPEC), and remarkably potent activity (lethal dose of 90% < 30 nM) against a vancomycin resistant Enterococcus faecium (PubMed:12244054, PubMed:12527768, PubMed:17150966, PubMed:25075772, PubMed:33818125). Causes loss of bacterial membrane integrity (PubMed:17150966). Probably contributes to urinary tract sterility (PubMed:25075772). Bactericidal activity is independent of RNase activity (PubMed:17150966).BIOPHYSICOCHEMICAL PROPERTIES Detected in urine.TISSUE SPECIFICITY Expressed in collecting ducts in kidney, and in apical uroepithelium in bladder (at protein level) (PubMed:25075772). Expressed in various epithelial tissues including skin, respiratory tract, genito-urinary tract and, at a low level, in the gut (PubMed:12244054). Expressed in liver, kidney, skeletal muscle and heart (PubMed:12527768).INDUCTION Up-regulated in response to the cytokines IL1B, IFNG and TNF (PubMed:12244054). Strongly up-regulated in response to the bacterium P.aeruginosa (PubMed:12244054). Moderately up-regulated in response to S.aureus, E.coli and S.pyogenes (PubMed:12244054). Up-regulated in kidney in response to infection (PubMed:25075772).MASS SPECTROMETRY Belongs to the pancreatic ribonuclease family.
descriptionrecommendedName: Ribonuclease 7 shortName: RNase 7 ecNumber evidence="3 4 7"3.1.27.- alternativeName: Skin-derived antimicrobial protein 2 shortName: SAP-2
geneNameRNASE7
UNQ2516/PRO6006
identifierQ9H1E1
isSequenceChangedFALSE
keyword3D-structure
Antibiotic
Antimicrobial
Direct protein sequencing
Disulfide bond
Endonuclease
Glycoprotein
Hydrolase
Nuclease
Proteomics identification
Reference proteome
Secreted
Signal
modified[InstanceEdit:9836292] Weiser, Joel, 2023-05-25
[InstanceEdit:9852000] Weiser, Joel, 2023-11-03
[InstanceEdit:9917590] Weiser, Joel, 2024-08-09
[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
nameRNASE7
referenceDatabase[ReferenceDatabase:2] UniProt
referenceGene[ReferenceDNASequence:8993277] ENSEMBL:ENSG00000165799 RNASE7 [Homo sapiens]
secondaryIdentifierRNAS7_HUMAN
P80927
P83685
Q546N3
sequenceLength156
species[Species:48887] Homo sapiens
(referenceEntity)[EntityWithAccessionedSequence:6803118] RNASE7 [extracellular region] [Homo sapiens]
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