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Details on Person UniProt:Q93091 RNASE6
| Class:Id | ReferenceGeneProduct:63409 |
|---|---|
| _chainChangeLog | signal peptide:1-23 added on Fri February 6 2015;chain:24-150 added on Fri February 6 2015 |
| _displayName | UniProt:Q93091 RNASE6 |
| _timestamp | 2024-11-03 20:11:52 |
| chain | signal peptide:1-23 chain:24-150 |
| checksum | 4C1F722066BCC13A |
| comment | FUNCTION Ribonuclease which shows a preference for the pyrimidines uridine and cytosine (PubMed:27013146, PubMed:8836175). Has potent antibacterial activity against a range of Gram-positive and Gram-negative bacteria, including P.aeruginosa, A.baumanii, M.luteus, S.aureus, E.faecalis, E.faecium, S.saprophyticus and E.coli (PubMed:25075772, PubMed:27089320). Causes loss of bacterial membrane integrity, and also promotes agglutination of Gram-negative bacteria (PubMed:27089320). Probably contributes to urinary tract sterility (PubMed:25075772). Bactericidal activity is independent of RNase activity (PubMed:27089320).BIOPHYSICOCHEMICAL PROPERTIES Interacts (via N-terminus) with bacterial lipopolysaccharide (LPS).SUBCELLULAR LOCATION Highly expressed in spleen (at protein level) (PubMed:25075772, PubMed:8836175). Has little or no expression in healthy kidneys (at protein level) (PubMed:25075772). Detected in interstitial leukocytes in infected kidneys (at protein level) (PubMed:25075772). Expressed in ureter where it localizes to urothelial and submucosal leukocytes (at protein level) (PubMed:25075772). Strong expression in lung and thymus, and lower expression in heart, placenta, pancreas, liver, brain and skeletal muscle (PubMed:25075772, PubMed:8836175). Also expressed in monocytes and neutrophils (PubMed:8836175).INDUCTION Up-regulated in CD14+ monocytes in response to the uropathogenic E.coli strain CFT073.SIMILARITY Belongs to the pancreatic ribonuclease family. |
| description | recommendedName: Ribonuclease K6 shortName: RNase K6 ecNumber evidence="7 9"3.1.27.- |
| geneName | RNASE6 RNS6 |
| identifier | Q93091 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Antibiotic Antimicrobial Disulfide bond Endonuclease Glycoprotein Hydrolase Lysosome Nuclease Proteomics identification Reference proteome Secreted Signal |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | RNASE6 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8990371] ENSEMBL:ENSG00000169413 RNASE6 [Homo sapiens] |
| secondaryIdentifier | RNAS6_HUMAN |
| sequenceLength | 150 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:6803140] RNASE6 [extracellular region] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q93091 RNASE6 (63409)
