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Details on Person UniProt:P07998 RNASE1
| Class:Id | ReferenceGeneProduct:63405 |
|---|---|
| _chainChangeLog | signal peptide:1-28 added on Sat February 7 2015;chain:29-156 added on Sat February 7 2015 |
| _displayName | UniProt:P07998 RNASE1 |
| _timestamp | 2024-11-03 20:16:23 |
| chain | signal peptide:1-28 chain:29-156 |
| checksum | F63B17B8B55115F9 |
| comment | FUNCTION Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single-stranded and double-stranded RNA.CATALYTIC ACTIVITY an [RNA] containing cytidine + H2O = an [RNA]-3'-cytidine-3'-phosphate + a 5'-hydroxy-ribonucleotide-3'-[RNA].CATALYTIC ACTIVITY an [RNA] containing uridine + H2O = an [RNA]-3'-uridine-3'-phosphate + a 5'-hydroxy-ribonucleotide-3'-[RNA].SUBUNIT Monomer. Interacts with and forms tight 1:1 complexes with RNH1. Dimerization of two such complexes may occur. Interaction with RNH1 inhibits this protein.INTERACTION Pancreas and other tissues and body fluids (indicating it may have other physiological functions besides its role in digestion).PTM N-linked glycans are of complex type.SIMILARITY Belongs to the pancreatic ribonuclease family. |
| description | recommendedName: Ribonuclease pancreatic ecNumber: 4.6.1.18 alternativeName: HP-RNase alternativeName: RIB-1 alternativeName: RNase UpI-1 alternativeName: Ribonuclease 1 shortName: RNase 1 alternativeName: Ribonuclease A shortName: RNase A |
| geneName | RNASE1 RIB1 RNS1 |
| identifier | P07998 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Direct protein sequencing Disulfide bond Endonuclease Glycoprotein Hydrolase Lyase Nuclease Proteomics identification Reference proteome Secreted Signal |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | RNASE1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8960234] ENSEMBL:ENSG00000129538 RNASE1 [Homo sapiens] |
| secondaryIdentifier | RNAS1_HUMAN B2R589 D3DS06 Q16830 Q16869 Q1KHR2 Q6ICS5 Q9UCB4 Q9UCB5 |
| sequenceLength | 156 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:8960715] RNASE1 [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:9615716] RNASE1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9625180] RNASE1 [lysosomal lumen] [Homo sapiens] [EntityWithAccessionedSequence:9631105] RNASE1 [late endosome lumen] [Homo sapiens] [EntityWithAccessionedSequence:9923807] RNASE1 [zymogen granule] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P07998 RNASE1 (63405)
