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Details on Person UniProt:P78317 RNF4

Class:Id	ReferenceGeneProduct:63377
_chainChangeLog	chain:1-190 added on Fri February 6 2015
_displayName	UniProt:P78317 RNF4
_timestamp	2024-11-03 19:53:43
chain	chain:1-190
checksum	E5E3AE4A9B28CF9D
comment	FUNCTION E3 ubiquitin-protein ligase which binds polysumoylated chains covalently attached to proteins and mediates 'Lys-6'-, 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination of those substrates and their subsequent targeting to the proteasome for degradation (PubMed:18408734, PubMed:19307308, PubMed:35013556). Regulates the degradation of several proteins including PML and the transcriptional activator PEA3 (PubMed:18408734, PubMed:19307308, PubMed:20943951). Involved in chromosome alignment and spindle assembly, it regulates the kinetochore CENPH-CENPI-CENPK complex by targeting polysumoylated CENPI to proteasomal degradation (PubMed:20212317). Regulates the cellular responses to hypoxia and heat shock through degradation of respectively EPAS1 and PARP1 (PubMed:19779455, PubMed:20026589). Alternatively, it may also bind DNA/nucleosomes and have a more direct role in the regulation of transcription for instance enhancing basal transcription and steroid receptor-mediated transcriptional activation (PubMed:12885770). Catalyzes ubiquitination of sumoylated PARP1 in response to PARP1 trapping to chromatin, leading to PARP1 removal from chromatin by VCP/p97 (PubMed:35013556).CATALYTIC ACTIVITY S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.PATHWAY Protein modification; protein ubiquitination.SUBUNIT Homodimer (via RING-type zinc finger domain) (By similarity). Interacts with GSC2 (By similarity). Interacts with AR/the androgen receptor and TBP (By similarity). Interacts with TCF20 (By similarity). Interacts with PATZ1 (PubMed:10713105). Interacts with TRPS1; negatively regulates TRPS1 transcriptional repressor activity (PubMed:12885770). Interacts with PML (isoform PML-1, isoform PML-2, isoform PML-3, isoform PML-4, isoform PML-5 and isoform PML-6) (PubMed:15707587, PubMed:20943951, PubMed:23028697). Interacts with PRDM1/Blimp-1 (PubMed:28842558).INTERACTION Widely expressed at low levels in many tissues; highly expressed in testis.DOMAIN The SUMO interaction motifs (SIMs) mediates the binding to polysumoylated substrate.DOMAIN The RING-type zinc finger domain is required for the ubiquitination of polysumoylated substrates.PTM Sumoylated; conjugated by one or two SUMO1 moieties.PTM Autoubiquitinated.
description	recommendedName: fullName evidence="21"E3 ubiquitin-protein ligase RNF4 ecNumber evidence="16"2.3.2.27 alternativeName: fullName evidence="21"RING finger protein 4 alternativeName: fullName evidence="19"Small nuclear ring finger protein shortName evidence="19"Protein SNURF
geneName	RNF4 SNURF RES4-26
identifier	P78317
isSequenceChanged	FALSE
keyword	3D-structure Activator Alternative splicing Cytoplasm DNA-binding Metal-binding Nucleus Phosphoprotein Proteomics identification Reference proteome Transcription Transcription regulation Transferase Ubl conjugation Ubl conjugation pathway Zinc Zinc-finger
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
name	RNF4
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:8993278] ENSEMBL:ENSG00000063978 RNF4 [Homo sapiens]
secondaryIdentifier	RNF4_HUMAN B2R6D6 D6RF58 Q49AR8
sequenceLength	190
species	[Species:48887] Homo sapiens
(isoformParent)	[ReferenceIsoform:8976210] UniProt:P78317-1 RNF4 [Homo sapiens] [ReferenceIsoform:8976211] UniProt:P78317-2 RNF4 [Homo sapiens]
(referenceEntity)	[EntityWithAccessionedSequence:975974] RNF4 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:5684076] RNF4 [nucleoplasm] [Homo sapiens]
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No pathways have been reviewed or authored by UniProt:P78317 RNF4 (63377)