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Details on Person UniProt:O60896 RAMP3
| Class:Id | ReferenceGeneProduct:63337 |
|---|---|
| _chainChangeLog | signal peptide:1-23 added on Fri February 6 2015;chain:24-148 added on Fri February 6 2015 |
| _displayName | UniProt:O60896 RAMP3 |
| _timestamp | 2025-05-21 21:14:29 |
| chain | signal peptide:1-23 chain:24-148 |
| checksum | EEEE312496EF513C |
| comment | FUNCTION Accessory protein that interacts with and modulates the function of G-protein coupled receptors including calcitonin gene-related peptide type 1 receptor (CALCRL), calcitonin receptor (CALCR) and G-protein coupled estrogen receptor 1 (GPER1) (PubMed:23674134, PubMed:9620797). Required for the transport of CALCRL and GPER1 receptors to the plasma membrane (PubMed:23674134, PubMed:9620797). Plays a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner (PubMed:23674134). Together with CALCRL, form a receptor complex for adrenomedullin/ADM and intermedin/ADM2 (PubMed:32296767). Together with CALCR, act as a receptor complex for amylin/IAPP (PubMed:35324283).SUBUNIT Heterodimer of CALCRL and RAMP3; interaction induces allosteric modulation of CALCRL function and ligand specificity for adrenomedullin/ADM and intermedin/ADM2 (PubMed:32296767). Heterodimer of CALCR and RAMP3; interaction form the receptor complex AMYR3 for amylin/IAPP (PubMed:35324283). Interacts with GPER1 (PubMed:23674134).INTERACTION Moves from intracellular puncta to the plasma membrane in a RAMP3-dependent manner.TISSUE SPECIFICITY Strongly expressed in lung, breast, immune system and fetal tissues.SIMILARITY Belongs to the RAMP family. |
| description | recommendedName: Receptor activity-modifying protein 3 alternativeName: Calcitonin-receptor-like receptor activity-modifying protein 3 shortName: CRLR activity-modifying protein 3 |
| geneName | RAMP3 |
| identifier | O60896 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Cell membrane Disulfide bond Glycoprotein Membrane Proteomics identification Receptor Reference proteome Signal Transmembrane Transmembrane helix Transport |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9948485] Weiser, Joel, 2025-05-21 |
| name | RAMP3 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8992091] ENSEMBL:ENSG00000122679 RAMP3 [Homo sapiens] |
| secondaryIdentifier | RAMP3_HUMAN Q7Z2Y1 |
| sequenceLength | 148 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:420191] RAMP3 [plasma membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:O60896 RAMP3 (63337)
