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Details on Person UniProt:Q15835 GRK1
| Class:Id | ReferenceGeneProduct:63141 |
|---|---|
| _chainChangeLog | chain:1-560 added on Fri February 6 2015;propeptide:561-563 added on Fri February 6 2015 |
| _displayName | UniProt:Q15835 GRK1 |
| _timestamp | 2025-05-21 21:55:44 |
| chain | chain:1-560 propeptide:561-563 |
| checksum | 1244DCB97D40F53D |
| comment | FUNCTION Retina-specific kinase involved in the signal turnoff via phosphorylation of rhodopsin (RHO), the G protein- coupled receptor that initiates the phototransduction cascade (PubMed:15946941). This rapid desensitization is essential for scotopic vision and permits rapid adaptation to changes in illumination (By similarity). May play a role in the maintenance of the outer nuclear layer in the retina (By similarity).CATALYTIC ACTIVITY L-threonyl-[rhodopsin] + ATP = O-phospho-L-threonyl-[rhodopsin] + ADP + H(+)CATALYTIC ACTIVITY L-seryl-[rhodopsin] + ATP = O-phospho-L-seryl-[rhodopsin] + ADP + H(+)ACTIVITY REGULATION Inhibited by RCVRN, which prevents the interaction between GRK1 and RHO (By similarity). Inhibition is calcium-dependent (By similarity). Inhibited by phosphorylation of Ser-21.BIOPHYSICOCHEMICAL PROPERTIES Interacts (via N-terminus) with RCVRN (via C-terminus); the interaction is Ca(2+)-dependent (By similarity). Interacts (when prenylated) with PDE6D; this promotes release from membranes (By similarity). May form a complex composed of RHO, GRK1 and RCVRN in a Ca(2+)-dependent manner; RCVRN prevents the interaction between GRK1 and RHO (By similarity).SUBCELLULAR LOCATION Subcellular location is not affected by light or dark conditions.TISSUE SPECIFICITY Retinal-specific. Expressed in rods and cones cells.PTM Autophosphorylated, Ser-21 is a minor site of autophosphorylation compared to Ser-491 and Thr-492 (By similarity). Phosphorylation at Ser-21 is regulated by light and activated by cAMP.PTM Farnesylation is required for full activity.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. |
| description | recommendedName: Rhodopsin kinase GRK1 shortName: RK ecNumber evidence="10"2.7.11.14 alternativeName: fullName evidence="15"G protein-coupled receptor kinase 1 |
| geneName | GRK1 RHOK |
| identifier | Q15835 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure ATP-binding Cell projection Congenital stationary night blindness Disease variant Kinase Lipoprotein Membrane Methylation Nucleotide-binding Phosphoprotein Prenylation Proteomics identification Reference proteome Sensory transduction Serine/threonine-protein kinase Transferase Vision |
| modified | [InstanceEdit:84067] Schmidt, EE, 2003-12-18 04:29:09 [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:3445779] Weiser, JD [InstanceEdit:4341137] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:5691543] Weiser, JD [InstanceEdit:8944791] Weiser, JD [InstanceEdit:8987656] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9627708] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9666080] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9706439] Weiser, JD [InstanceEdit:9715482] Weiser, JD [InstanceEdit:9730071] Weiser, JD [InstanceEdit:9750299] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9948485] Weiser, Joel, 2025-05-21 |
| name | GRK1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8997404] ENSEMBL:ENSG00000185974 GRK1 [Homo sapiens] |
| secondaryIdentifier | GRK1_HUMAN Q53X14 |
| sequenceLength | 563 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:63140] S-farn-GRK1 [photoreceptor disc membrane] [Homo sapiens] [EntityWithAccessionedSequence:74507] Far-GRK1 [plasma membrane] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:74506] farnesylated residue at unknown position [GroupModifiedResidue:2581491] S-farnesyl-L-cysteine (farnesyl group) at 560 |
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No pathways have been reviewed or authored by UniProt:Q15835 GRK1 (63141)
