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Details on Person UniProt:P31350 RRM2
| Class:Id | ReferenceGeneProduct:63137 |
|---|---|
| _chainChangeLog | chain:1-389 added on Fri February 6 2015 |
| _displayName | UniProt:P31350 RRM2 |
| _timestamp | 2025-02-21 20:13:51 |
| chain | chain:1-389 |
| checksum | 10E6F5F84D34DA94 |
| comment | FUNCTION Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling.CATALYTIC ACTIVITY a 2'-deoxyribonucleoside 5'-diphosphate + [thioredoxin]-disulfide + H2O = a ribonucleoside 5'-diphosphate + [thioredoxin]-dithiolCOFACTOR Binds 2 iron ions per subunit.SUBUNIT Heterodimer of a large and a small subunit. Interacts (via Cy motif and when phosphorylated at Thr-33) with CCNF; the interaction occurs exclusively in G2 and early M (PubMed:22632967).INTERACTION Localized to the cytoplasm in S phase cells. May localize to the nucleus in G2 phase cells.ALTERNATIVE PRODUCTS Up-regulated in response to DNA damage induced by doxorubicin, camptothecin, UV-C, methyl methanesulfonate, nocodazole, or gamma-irradiation.PTM Phosphorylation on Ser-20 relieves the inhibitory effect on Wnt signaling. Phosphorylated on Thr-33 by CDK1 and CDK2; predominantly in G2 and M phase (PubMed:22632967).PTM Ubiquitinated by the SCF(CCNF) E3 ubiquitin-protein ligase complex; leading to its degradation by the proteasome.MISCELLANEOUS Two distinct regulatory sites have been defined: the specificity site, which controls substrate specificity, and the activity site which regulates overall catalytic activity. A substrate-binding catalytic site, located on M1, is formed only in the presence of the second subunit M2.SIMILARITY Belongs to the ribonucleoside diphosphate reductase small chain family.SEQUENCE CAUTION Ribonucleotide reductase entry |
| description | recommendedName: Ribonucleoside-diphosphate reductase subunit M2 ecNumber: 1.17.4.1 alternativeName: Ribonucleotide reductase small chain alternativeName: Ribonucleotide reductase small subunit |
| geneName | RRM2 RR2 |
| identifier | P31350 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cytoplasm Deoxyribonucleotide synthesis Iron Metal-binding Nucleus Oxidoreductase Phosphoprotein Proteomics identification Reference proteome Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | RRM2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8961973] ENSEMBL:ENSG00000171848 RRM2 [Homo sapiens] |
| secondaryIdentifier | RIR2_HUMAN B2R9B5 J3KP43 Q5WRU7 |
| sequenceLength | 389 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8968029] UniProt:P31350-1 RRM2 [Homo sapiens] [ReferenceIsoform:8968030] UniProt:P31350-2 RRM2 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:73639] RRM2 [cytosol] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P31350 RRM2 (63137)
