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Details on Person UniProt:P04843 RPN1
| Class:Id | ReferenceGeneProduct:63115 |
|---|---|
| _chainChangeLog | signal peptide:1-23 added on Fri February 6 2015;chain:24-607 added on Fri February 6 2015 |
| _displayName | UniProt:P04843 RPN1 |
| _timestamp | 2025-05-21 21:20:58 |
| chain | signal peptide:1-23 chain:24-607 |
| checksum | A2351A9CFABAEB6C |
| comment | FUNCTION Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (PubMed:31831667). N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity (By similarity).PATHWAY Protein modification; protein glycosylation.SUBUNIT Component of the oligosaccharyltransferase (OST) complex (PubMed:31831667). OST exists in two different complex forms which contain common core subunits RPN1, RPN2, OST48, OST4, DAD1 and TMEM258, either STT3A or STT3B as catalytic subunits, and form-specific accessory subunits (PubMed:23606741, PubMed:25135935, PubMed:31831667). STT3A complex assembly occurs through the formation of 3 subcomplexes. Subcomplex 1 contains RPN1 and TMEM258, subcomplex 2 contains the STT3A-specific subunits STT3A, DC2/OSTC, and KCP2 as well as the core subunit OST4, and subcomplex 3 contains RPN2, DAD1, and OST48. The STT3A complex can form stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes (By similarity). Interacts with TMEM35A/NACHO (By similarity).INTERACTION Identified by mass spectrometry in melanosome fractions from stage I to stage IV.TISSUE SPECIFICITY Expressed in all tissues tested.PTM Ubiquitinated by the ECS(ASB11) complex. Ubiquitinated by RNF128, leading to degradation in a proteasome/lysosome-dependent manner (PubMed:39567208).PTM Ufmylated by UFL1 in response to endoplasmic reticulum stress, promoting reticulophagy of endoplasmic reticulum sheets.SIMILARITY Belongs to the OST1 family. |
| description | recommendedName: fullName evidence="14"Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 alternativeName: Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 67 kDa subunit alternativeName: Ribophorin I shortName: RPN-I alternativeName: Ribophorin-1 |
| geneName | RPN1 |
| identifier | P04843 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Endoplasmic reticulum Glycoprotein Isopeptide bond Membrane Proteomics identification Reference proteome Signal Transmembrane Transmembrane helix Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9948485] Weiser, Joel, 2025-05-21 |
| name | RPN1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8996231] ENSEMBL:ENSG00000163902 RPN1 [Homo sapiens] |
| secondaryIdentifier | RPN1_HUMAN B2R5Z0 D3DNB6 Q68DT1 |
| sequenceLength | 607 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:264994] RPN1 [endoplasmic reticulum membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P04843 RPN1 (63115)
