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Details on Person UniProt:P84095 RHOG
| Class:Id | ReferenceGeneProduct:63098 |
|---|---|
| _chainChangeLog | chain:1-188 added on Fri February 6 2015;propeptide:189-191 added on Fri February 6 2015 |
| _displayName | UniProt:P84095 RHOG |
| _timestamp | 2024-11-03 19:43:09 |
| chain | chain:1-188 propeptide:189-191 |
| checksum | 0C4FE9C54140F499 |
| comment | FUNCTION Plays a role in immunological synaptic F-actin density and architecture organization (PubMed:33513601). Regulates actin reorganization in lymphocytes, possibly through the modulation of Rac1 activity (PubMed:33513601). Required for the formation of membrane ruffles during macropinocytosis (PubMed:15133129). Plays a role in cell migration and is required for the formation of cup-like structures during trans-endothelial migration of leukocytes (PubMed:17875742). Binds phospholipids in an activation-dependent manner; thereby acting as an anchor for other proteins to the plasma membrane (PM) (PubMed:33513601). Plays a role in exocytosis of cytotoxic granules (CG) by lymphocytes/Component of the exocytosis machinery in natural killer (NK) and CD8+ T cells (PubMed:33513601). Promotes the docking of cytotoxic granules (CG) to the plasma membrane through the interaction with UNC13D (PubMed:33513601). Involved in the cytotoxic activity of lymphocytes/primary CD8+ T cells (PubMed:33513601).FUNCTION (Microbial infection) In case of Salmonella enterica infection, activated by SopB and ARHGEF26/SGEF, which induces cytoskeleton rearrangements and promotes bacterial entry.SUBUNIT Interacts with ARHGEF26 (PubMed:15133129). Interacts with ARHGEF16 (PubMed:20679435). Interacts with UNC13D; the interaction increases RhoG affinity to the membrane lipids, targets UNC13D to membrane lipids and facilitates cytotoxic granule (CG) docking to the plasma membrane (PubMed:33513601).INTERACTION (Microbial infection) Glucosylated at Thr-35 by C.difficile toxin TcdB.PTM (Microbial infection) Glycosylated (O-GlcNAcylated) at Thr-35 by C.novyi toxin TcdA (PubMed:8810274). O-GlcNAcylation completely prevents the recognition of the downstream effector, blocking the GTPases in their inactive form, leading to actin cytoskeleton disruption (PubMed:8810274).DISEASE Defects in RHOG may be the cause of a severe hemophagocytic lymphohistiocytosis (HLH). The affected patient shows characteristic HLH features, such as hemophagocytosis, hepatosplenomegaly, fever, cytopenias, low hemoglobin, hypertriglyceridemia, and elevated ferritin and soluble interleukin-2 receptor.SIMILARITY Belongs to the small GTPase superfamily. Rho family. |
| description | recommendedName: Rho-related GTP-binding protein RhoG |
| geneName | RHOG ARHG |
| identifier | P84095 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure ADP-ribosylation Cell membrane Disease variant Glycoprotein GTP-binding Lipoprotein Membrane Methylation Nucleotide-binding Phosphoprotein Prenylation Proteomics identification Reference proteome |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | RHOG |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9000274] ENSEMBL:ENSG00000177105 RHOG [Homo sapiens] |
| secondaryIdentifier | RHOG_HUMAN P35238 Q8NI04 |
| sequenceLength | 191 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:194880] RHOG [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:194909] RHOG [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:5672084] RHOG [endoplasmic reticulum membrane] [Homo sapiens] [EntityWithAccessionedSequence:6804965] RHOG [secretory granule membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P84095 RHOG (63098)
