Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:P02753 RBP4
| Class:Id | ReferenceGeneProduct:62956 |
|---|---|
| _chainChangeLog | signal peptide:1-18 added on Fri February 6 2015;chain:19-201 added on Fri February 6 2015;chain:19-200 added on Fri February 6 2015;chain:19-199 added on Fri February 6 2015;chain:19-197 added on Fri February 6 2015;chain:19-194 added on Fri February 6 2015 |
| _displayName | UniProt:P02753 RBP4 |
| _timestamp | 2025-05-21 21:26:37 |
| chain | signal peptide:1-18 chain:19-201 chain:19-200 chain:19-199 chain:19-197 chain:19-194 |
| checksum | 660C6DD8CC9B811A |
| comment | FUNCTION Retinol-binding protein that mediates retinol transport in blood plasma (PubMed:5541771). Delivers retinol from the liver stores to the peripheral tissues (Probable). Transfers the bound all-trans retinol to STRA6, that then facilitates retinol transport across the cell membrane (PubMed:22665496).SUBUNIT Interacts with TTR (PubMed:10052934, PubMed:19021760, PubMed:5541771, PubMed:7754382). Interaction with TTR prevents its loss by filtration through the kidney glomeruli (Probable). Interacts with STRA6 (PubMed:22665496, PubMed:25910211).INTERACTION Detected in blood plasma and in urine (at protein level).MASS SPECTROMETRY The disease is caused by variants affecting the gene represented in this entry. Loss of functional RBP4 protein results in serum retinol deficiency. Lack of normal levels of retinol impairs the visual cycle leading to night blindness at early stages; prolonged deficiency may lead to retinal degeneration. Additionally, retinol deficiency may result in dry skin, increased susceptibility to infection and acne (PubMed:23189188).DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the calycin superfamily. Lipocalin family.SEQUENCE CAUTION Truncated N-terminus.ONLINE INFORMATION Retinol-binding protein 4 entry |
| description | recommendedName: Retinol-binding protein 4 alternativeName: Plasma retinol-binding protein shortName: PRBP shortName: RBP component recommendedName: Plasma retinol-binding protein(1-182) /component component recommendedName: Plasma retinol-binding protein(1-181) /component component recommendedName: Plasma retinol-binding protein(1-179) /component component recommendedName: Plasma retinol-binding protein(1-176) /component |
| geneName | RBP4 PRO2222 |
| identifier | P02753 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Direct protein sequencing Disease variant Disulfide bond Methylation Microphthalmia Proteomics identification Reference proteome Retinol-binding Secreted Sensory transduction Signal Transport Vision Vitamin A |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9948485] Weiser, Joel, 2025-05-21 |
| name | RBP4 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8989175] ENSEMBL:ENSG00000138207 RBP4 [Homo sapiens] |
| secondaryIdentifier | RET4_HUMAN D3DR38 O43478 O43479 Q5VY24 Q8WWA3 Q9P178 |
| sequenceLength | 201 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:2453671] RBP4(19-201) [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:2453675] RBP4(19-201) [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:2471928] RBP4 G75D [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:2471954] RBP4 I41N [extracellular region] [Homo sapiens] |
| (referenceSequence) | [ReplacedResidue:2471931] glycine 75 replaced with L-aspartic acid [ReplacedResidue:2471949] L-isoleucine 41 replaced with L-asparagine |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P02753 RBP4 (62956)
