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Details on Person UniProt:P04090 RLN2
| Class:Id | ReferenceGeneProduct:62922 |
|---|---|
| _chainChangeLog | signal peptide:1-24 added on Fri February 6 2015;peptide:25-53 added on Fri February 6 2015;propeptide:56-157 added on Fri February 6 2015;peptide:162-185 added on Fri February 6 2015 |
| _displayName | UniProt:P04090 RLN2 |
| _timestamp | 2024-11-03 19:48:12 |
| chain | signal peptide:1-24 peptide:25-53 propeptide:56-157 peptide:162-185 |
| checksum | AC73DBDE2090091B |
| comment | FUNCTION Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix.SUBUNIT Heterodimer of a B chain and an A chain linked by two disulfide bonds.SUBCELLULAR LOCATION Isoform 1 is expressed in the ovary during pregnancy. Also expressed in placenta, decidua and prostate. Isoform 2 is relatively abundant in placenta. It is in much lower abundance in the prostate gland. Not detected in the ovary.SIMILARITY Belongs to the insulin family. |
| description | recommendedName: Prorelaxin H2 component recommendedName: Relaxin B chain /component component recommendedName: Relaxin A chain /component |
| geneName | RLN2 |
| identifier | P04090 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Hormone Proteomics identification Pyrrolidone carboxylic acid Reference proteome Secreted Signal |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | RLN2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8990938] ENSEMBL:ENSG00000107014 RLN2 [Homo sapiens] |
| secondaryIdentifier | REL2_HUMAN A0AVM0 Q99936 Q9UCX3 Q9UQJ2 |
| sequenceLength | 185 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:152847] UniProt:P04090-2 RLN2 [Homo sapiens] [ReferenceIsoform:402364] UniProt:P04090-1 RLN2 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:444870] RLN2(25-53) [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:444896] RLN2(162-185) [extracellular region] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P04090 RLN2 (62922)
