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Details on Person UniProt:O95980 RECK
| Class:Id | ReferenceGeneProduct:62912 |
|---|---|
| _chainChangeLog | signal peptide:1-22 added on Sat February 7 2015;chain:23-942 added on Sat February 7 2015;propeptide:943-971 added on Sat February 7 2015 |
| _displayName | UniProt:O95980 RECK |
| _timestamp | 2024-11-03 20:21:03 |
| chain | signal peptide:1-22 chain:23-942 propeptide:943-971 |
| checksum | 173D47D6AEE6F834 |
| comment | FUNCTION Functions together with ADGRA2 to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B) (PubMed:28289266, PubMed:30026314). Plays a key role in Wnt7-specific responses: required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (By similarity). Acts as a Wnt7-specific coactivator of canonical Wnt signaling by decoding Wnt ligands: acts by interacting specifically with the disordered linker region of Wnt7, thereby conferring ligand selectivity for Wnt7 (PubMed:30026314). ADGRA2 is then required to deliver RECK-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 complex (PubMed:30026314). Also acts as a serine protease inhibitor: negatively regulates matrix metalloproteinase-9 (MMP9) by suppressing MMP9 secretion and by direct inhibition of its enzymatic activity (PubMed:18194466, PubMed:9789069). Also inhibits metalloproteinase activity of MMP2 and MMP14 (MT1-MMP) (PubMed:9789069).SUBUNIT Interacts (via knot repeats) with WNT7A (via disordered linker region); the interaction is direct (PubMed:30026314). Interacts (via knot repeats) with WNT7B (via disordered linker region); the interaction is direct (PubMed:30026314). Interacts with ADGRA2; the interaction is direct (PubMed:30026314). Interacts with MMP9 (PubMed:9789069).INTERACTION Expressed in various tissues and untransformed cells (PubMed:9789069). It is undetectable in tumor-derived cell lines and oncogenically transformed cells (PubMed:9789069).DOMAIN The Kazal-like domains mediate the serine protease inhibitor activity.PTM N-glycosylated.SIMILARITY Belongs to the RECK family. |
| description | recommendedName: fullName evidence="8"Reversion-inducing cysteine-rich protein with Kazal motifs shortName evidence="8"hRECK alternativeName: fullName evidence="10"Suppressor of tumorigenicity 15 protein |
| geneName | RECK ST15 |
| identifier | O95980 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Cell membrane Disulfide bond Glycoprotein GPI-anchor Lipoprotein Membrane Protease inhibitor Proteomics identification Reference proteome Repeat Serine protease inhibitor Signal Tumor suppressor Wnt signaling pathway |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9909836] Weiser, Joel, 2024-05-14 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | RECK |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8990937] ENSEMBL:ENSG00000122707 RECK [Homo sapiens] |
| secondaryIdentifier | RECK_HUMAN B2RNS1 Q5W0K6 Q8WX37 |
| sequenceLength | 971 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:8940434] RECK [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:8940687] GPI-RECK [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:8941046] cleaved GPI-RECK [extracellular region] [Homo sapiens] |
| (referenceSequence) | [GroupModifiedResidue:8940705] L-serine amide (GPI-anchor amidated amino acid carboxyl end residue(1−)) at 942 [GroupModifiedResidue:8941060] L-serine amide (6-O-(2-aminoethylphosphono)-alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-alpha-D-Man-(1->4)-alpha-D-GlcN-(1->6)-D-myo-inositol group) at 942 |
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No pathways have been reviewed or authored by UniProt:O95980 RECK (62912)
