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Details on Person UniProt:P18615 NELFE
| Class:Id | ReferenceGeneProduct:62908 |
|---|---|
| _chainChangeLog | chain:1-380 added on Sat February 7 2015 |
| _displayName | UniProt:P18615 NELFE |
| _timestamp | 2024-11-03 20:02:06 |
| chain | chain:1-380 |
| checksum | 95EB422B5E07410B |
| comment | FUNCTION Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II (PubMed:10199401, PubMed:27256882). The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex (PubMed:11940650, PubMed:12612062, PubMed:27256882). Provides the strongest RNA binding activity of the NELF complex and may initially recruit the NELF complex to RNA (PubMed:18303858, PubMed:27256882, PubMed:27282391).FUNCTION (Microbial infection) The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II.SUBUNIT The NELF complex is composed of NELFA, NELFB, NELFCD (isoform NELF-C or isoform NELF-D) and NELFE (PubMed:10199401, PubMed:27282391). Interacts with NELFB (By similarity).SUBUNIT (Microbial infection) Binds to the HIV-1 TAR RNA which is located in the long terminal repeat (LTR) of HIV-1.INTERACTION Localizes to chromatin (PubMed:14701750). Phosphorylation by the P-TEFb complex promotes its release from chromatin (PubMed:14701750).ALTERNATIVE PRODUCTS Widely expressed. Expressed in heart, brain, lung, placenta, liver, skeletal muscle, kidney and pancreas.DOMAIN The RRM domain interacts with RNA, and is essential for NELF complex function. It is however not required for the NELF complex formation.PTM Phosphorylated by the P-TEFb complex at sites next to its RNA recognition motif, promoting its release from chromatin.PTM Sumoylated.PTM Poly-ADP-ribosylated by PARP1, thereby preventing RNA-binding and relieving transcription pausing.SIMILARITY Belongs to the RRM NELF-E family. |
| description | recommendedName: Negative elongation factor E shortName: NELF-E alternativeName: fullName evidence="15"RNA-binding protein RD |
| geneName | NELFE RD RDBP |
| identifier | P18615 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure ADP-ribosylation Alternative splicing Chromosome Coiled coil Direct protein sequencing Isopeptide bond Nucleus Phosphoprotein Proteomics identification Reference proteome Repeat Repressor RNA-binding Transcription Transcription regulation Ubl conjugation |
| modified | [InstanceEdit:84067] Schmidt, EE, 2003-12-18 04:29:09 [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:3445779] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:8934940] Weiser, JD [InstanceEdit:8987656] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9796772] Weiser, Joel [InstanceEdit:9819394] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | NELFE |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9002491] ENSEMBL:ENSG00000204356 NELFE [Homo sapiens] |
| secondaryIdentifier | NELFE_HUMAN A2BE08 B4DUN1 B4DYX9 Q5JP74 Q5JP75 Q96F56 Q9NPK2 |
| sequenceLength | 380 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8973896] UniProt:P18615-1 NELFE [Homo sapiens] [ReferenceIsoform:8973897] UniProt:P18615-3 NELFE [Homo sapiens] [ReferenceIsoform:8973898] UniProt:P18615-4 NELFE [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:62907] NELFE [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:170698] p-NELFE [nucleoplasm] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:170700] phosphorylated residue at unknown position |
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No pathways have been reviewed or authored by UniProt:P18615 NELFE (62908)
