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Details on Person UniProt:O94955 RHOBTB3
| Class:Id | ReferenceGeneProduct:62884 |
|---|---|
| _chainChangeLog | chain:1-611 added on Fri February 6 2015 |
| _displayName | UniProt:O94955 RHOBTB3 |
| _timestamp | 2026-02-20 21:53:15 |
| chain | chain:1-611 |
| checksum | 430ED42327AF08B6 |
| comment | FUNCTION Rab9-regulated ATPase required for endosome to Golgi transport. Involved in transport vesicle docking at the Golgi complex, possibly by participating in release M6PRBP1/TIP47 from vesicles to permit their efficient docking and fusion at the Golgi. Specifically binds Rab9, but not other Rab proteins. Has low intrinsic ATPase activity due to autoinhibition, which is relieved by Rab9.BIOPHYSICOCHEMICAL PROPERTIES Interacts with RAB9A and RAB9B (at lower level compared to RAB9A-binding). Interacts with M6PRBP1/TIP47.INTERACTION Ubiquitous (PubMed:12426103). Highly expressed in neural and cardiac tissues, pancreas, placenta and testis (PubMed:12426103).DOMAIN Although predicted to be a GTP-binding protein because of the presence of a Rho-like region, binds and hydrolyzes ATP (PubMed:19490898). In contrast to Rho-like proteins, the conserved Asp residue in position 138 in the G4 region is replaced by an Asn, decreasing the ability to bind GTP (PubMed:19490898).SEQUENCE CAUTION Extended N-terminus. |
| description | recommendedName: fullName evidence="6"Rho-related BTB domain-containing protein 3 ecNumber evidence="5"3.6.1.- |
| geneName | RHOBTB3 KIAA0878 |
| identifier | O94955 |
| isSequenceChanged | FALSE |
| keyword | ATP-binding Golgi apparatus Hydrolase Nucleotide-binding Proteomics identification Reference proteome Repeat Transport |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | RHOBTB3 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8989178] ENSEMBL:ENSG00000164292 RHOBTB3 [Homo sapiens] |
| secondaryIdentifier | RHBT3_HUMAN A0PJA4 A8K1W9 Q8IW06 |
| sequenceLength | 611 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:6813908] RHOBTB3 [trans-Golgi network membrane] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:O94955 RHOBTB3 (62884)
