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Details on Person UniProt:O95235 KIF20A
| Class:Id | ReferenceGeneProduct:62820 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Sat February 7 2015;chain:2-890 added on Sat February 7 2015;initiator methionine:1 for 62820 removed on Fri Nov 03 2023;initiator methionine: for 62820 added on Fri Nov 03 2023;initiator methionine: for 62820 removed on Fri Aug 15 2025;initiator methionine:1 for 62820 added on Fri Aug 15 2025 |
| _displayName | UniProt:O95235 KIF20A |
| _timestamp | 2025-08-15 21:00:42 |
| chain | initiator methionine:1 chain:2-890 |
| checksum | 6620264615496051 |
| comment | FUNCTION Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility.INTERACTION Localizes to the spindle midzone during anaphase and telophase.ALTERNATIVE PRODUCTS Phosphorylated by PLK1 at Ser-528 during mitosis, creating a docking site for PLK1 and recruiting PLK1 at central spindle.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. |
| description | recommendedName: Kinesin-like protein KIF20A alternativeName: GG10_2 alternativeName: Mitotic kinesin-like protein 2 shortName: MKlp2 alternativeName: Rab6-interacting kinesin-like protein alternativeName: Rabkinesin-6 |
| geneName | KIF20A MKLP2 RAB6KIFL |
| identifier | O95235 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing ATP-binding Cardiomyopathy Coiled coil Cytoplasm Cytoskeleton Disease variant Golgi apparatus Microtubule Motor protein Nucleotide-binding Phosphoprotein Protein transport Proteomics identification Reference proteome Transport |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | KIF20A |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8997227] ENSEMBL:ENSG00000112984 KIF20A [Homo sapiens] |
| secondaryIdentifier | KI20A_HUMAN B4DL79 D3DQB6 |
| sequenceLength | 890 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8967906] UniProt:O95235-1 KIF20A [Homo sapiens] [ReferenceIsoform:8967907] UniProt:O95235-2 KIF20A [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:156685] p-S528-KIF20A [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:156721] KIF20A [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:1015868] KIF20A [cytosol] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:156727] O-phospho-L-serine at 528 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:O95235 KIF20A (62820)
