Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:Q9NRW1 RAB6B
| Class:Id | ReferenceGeneProduct:62816 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-208 added on Fri February 6 2015;initiator methionine:1 removed on Wed November 4 2015;chain:2-208 removed on Wed November 4 2015;chain:1-208 added on Wed November 4 2015 |
| _displayName | UniProt:Q9NRW1 RAB6B |
| _timestamp | 2025-08-15 21:48:16 |
| chain | chain:1-208 |
| checksum | E81C831996E2446D |
| comment | FUNCTION The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between active GTP-bound and inactive GDP-bound states. In their active state, drive transport of vesicular carriers from donor organelles to acceptor organelles to regulate the membrane traffic that maintains organelle identity and morphology (By similarity). Recruits VPS13B to the Golgi membrane (PubMed:25492866). Regulates the compacted morphology of the Golgi (PubMed:26209634). Seems to have a role in retrograde membrane traffic at the level of the Golgi complex. May function in retrograde transport in neuronal cells (PubMed:17707369). Plays a role in neuron projection development (PubMed:25492866).CATALYTIC ACTIVITY GTP + H2O = GDP + phosphate + H(+)COFACTOR Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP, GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity, and GDP dissociation inhibitors which inhibit the dissociation of the nucleotide from the GTPase.SUBUNIT Interacts (GTP-bound) with BICD1 (via C-terminus); the interaction is direct (PubMed:17707369). Interacts (GDP-bound) with DYNLRB1 (PubMed:18044744). Interacts (GTP-bound) with APBA1/MINT1 isoform 2, also called Mint1_826, but not with isoform 1 (PubMed:23737971). Interacts (GTP-bound) with VPS13B isoform 2 (PubMed:25492866).INTERACTION Colocalizes with BICD1 at vesicular structures that align along microtubules.ALTERNATIVE PRODUCTS Predominantly expressed in brain.DOMAIN Switch 1, switch 2 and the interswitch regions are characteristic of Rab GTPases and mediate the interactions with Rab downstream effectors. The switch regions undergo conformational changes upon nucleotide binding which drives interaction with specific sets of effector proteins, with most effectors only binding to GTP-bound Rab.SIMILARITY Belongs to the small GTPase superfamily. Rab family. |
| description | recommendedName: Ras-related protein Rab-6B ecNumber evidence="12"3.6.5.2 |
| geneName | RAB6B |
| identifier | Q9NRW1 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cytoplasmic vesicle ER-Golgi transport Golgi apparatus GTP-binding Hydrolase Lipoprotein Magnesium Membrane Metal-binding Methylation Nucleotide-binding Phosphoprotein Prenylation Protein transport Proteomics identification Reference proteome Transport |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9948485] Weiser, Joel, 2025-05-21 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | RAB6B |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9003176] ENSEMBL:ENSG00000154917 RAB6B [Homo sapiens] |
| secondaryIdentifier | RAB6B_HUMAN B2R5Z9 B7Z337 D3DND3 Q92929 |
| sequenceLength | 208 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8972129] UniProt:Q9NRW1-1 RAB6B [Homo sapiens] [ReferenceIsoform:8972130] UniProt:Q9NRW1-2 RAB6B [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:6810983] RAB6B [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:6810985] RAB6B [trans-Golgi network membrane] [Homo sapiens] [EntityWithAccessionedSequence:8849249] RAB6B [Golgi membrane] [Homo sapiens] [EntityWithAccessionedSequence:8849252] RAB6B [endoplasmic reticulum membrane] [Homo sapiens] [EntityWithAccessionedSequence:8874055] GGC-RAB6B [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:8876081] GGC-RAB6B [trans-Golgi network membrane] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:8874056] S-geranylgeranyl-L-cysteine at 208 [ModifiedResidue:8874057] S-geranylgeranyl-L-cysteine at 206 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q9NRW1 RAB6B (62816)
