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Details on Person UniProt:P51148 RAB5C
| Class:Id | ReferenceGeneProduct:62812 |
|---|---|
| _chainChangeLog | chain:1-216 added on Fri February 6 2015 |
| _displayName | UniProt:P51148 RAB5C |
| _timestamp | 2026-02-20 22:26:01 |
| chain | chain:1-216 |
| checksum | AA42096C6EED77ED |
| comment | FUNCTION The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:16086013, PubMed:17562788). Involved in early endocytic trafficking (PubMed:16086013, PubMed:17562788). Required for EEA1 recruitment to early endosomes (PubMed:16086013, PubMed:17562788). Required for EGF and transferrin endocytosis and trafficking through early endosomes (PubMed:16086013, PubMed:17562788).CATALYTIC ACTIVITY GTP + H2O = GDP + phosphate + H(+)COFACTOR Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP (Probable). Regulated by GTPase activating proteins (GAPs) including SGSM3, which increase the GTP hydrolysis activity (PubMed:16086013, PubMed:17562788). Inhibited by GDP dissociation inhibitors (GDIs) (Probable).SUBUNIT Interacts with EEA1 (PubMed:12493736). Interacts with INCA1 (PubMed:21750715). Interacts with GDI1, GDI2, CHML and CHM; phosphorylation at Ser-85 disrupts this interaction (PubMed:29125462). Interacts (GTP-bound) with SGSM3; SGSM3 acts as a GAP (PubMed:17562788).INTERACTION Identified by mass spectrometry in melanosome fractions from stage I to stage IV.ALTERNATIVE PRODUCTS Switch I, switch II and the interswitch regions are characteristic of Rab GTPases and mediate the interactions with Rab downstream effectors. The switch regions undergo conformational changes upon nucleotide binding which drive interaction with specific sets of effector proteins, with most effectors only binding to GTP-bound Rab.PTM Phosphorylation of Ser-85 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including CHM, CHML and RAB GDP dissociation inhibitors GDI1 and GDI2.PTM (Microbial infection) Glycosylated on arginine residues by S.typhimurium protein Ssek3.SIMILARITY Belongs to the small GTPase superfamily. Rab family. |
| description | recommendedName: Ras-related protein Rab-5C ecNumber evidence="6 9"3.6.5.2 alternativeName: L1880 alternativeName: RAB5L |
| geneName | RAB5C RABL |
| identifier | P51148 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cell membrane Endosome Glycoprotein GTP-binding Hydrolase Lipoprotein Magnesium Membrane Metal-binding Nucleotide-binding Phosphoprotein Prenylation Protein transport Proteomics identification Reference proteome Transport |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | RAB5C |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8988610] ENSEMBL:ENSG00000108774 RAB5C [Homo sapiens] |
| secondaryIdentifier | RAB5C_HUMAN F8W1H5 Q6FH55 Q9P0Y5 |
| sequenceLength | 216 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8974007] UniProt:P51148-1 RAB5C [Homo sapiens] [ReferenceIsoform:8974008] UniProt:P51148-2 RAB5C [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:434198] RAB5C [cytoplasmic vesicle membrane] [Homo sapiens] [EntityWithAccessionedSequence:434334] RAB5C [Golgi membrane] [Homo sapiens] [EntityWithAccessionedSequence:6799338] RAB5C [azurophil granule membrane] [Homo sapiens] [EntityWithAccessionedSequence:6806265] RAB5C [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:8854157] RAB5C [early endosome membrane] [Homo sapiens] [EntityWithAccessionedSequence:8870413] RAB5C [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:8870436] GGC-RAB5C [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:8871129] GGC-RAB5C [clathrin-coated endocytic vesicle membrane] [Homo sapiens] [EntityWithAccessionedSequence:8875331] GGC-RAB5C [early endosome membrane] [Homo sapiens] [EntityWithAccessionedSequence:9837694] GGC-RAB5C [macropinosome membrane] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:8870394] S-geranylgeranyl-L-cysteine at 213 [ModifiedResidue:8870399] S-geranylgeranyl-L-cysteine at 214 |
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No pathways have been reviewed or authored by UniProt:P51148 RAB5C (62812)
