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Details on Person UniProt:P61018 RAB4B
| Class:Id | ReferenceGeneProduct:62800 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Sat February 7 2015;chain:2-213 added on Sat February 7 2015;initiator methionine:1 for 62800 removed on Fri Nov 03 2023;initiator methionine: for 62800 added on Fri Nov 03 2023;initiator methionine: for 62800 removed on Fri Aug 15 2025;initiator methionine:1 for 62800 added on Fri Aug 15 2025 |
| _displayName | UniProt:P61018 RAB4B |
| _timestamp | 2025-08-15 22:03:38 |
| chain | initiator methionine:1 chain:2-213 |
| checksum | 0C3D76DC3285DB98 |
| comment | FUNCTION The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB4B mediates endosomal tethering and fusion through the interaction with RUFY1 and RAB14 (PubMed:20534812). Acts as a regulator of platelet alpha-granule release during activation and aggregation of platelets (By similarity).CATALYTIC ACTIVITY GTP + H2O = GDP + phosphate + H(+)COFACTOR Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP. Regulated by GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity. Inhibited by GDP dissociation inhibitors (GDIs).SUBUNIT Interacts (GTP-bound form) with RUFY1; the interaction allows endosomal tethering and fusion.INTERACTION Switch 1, switch 2 and the interswitch regions are characteristic of Rab GTPases and mediate the interactions with Rab downstream effectors. The switch regions undergo conformational changes upon nucleotide binding which drives interaction with specific sets of effector proteins, with most effectors only binding to GTP-bound Rab.PTM Serotonylation of Gln-67 by TGM2 during activation and aggregation of platelets leads to constitutive activation of GTPase activity.SIMILARITY Belongs to the small GTPase superfamily. Rab family. |
| description | recommendedName: fullName evidence="9"Ras-related protein Rab-4B ecNumber evidence="2"3.6.5.2 |
| geneName | RAB4B RAB4 PP1596 |
| identifier | P61018 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing Cell membrane Endosome GTP-binding Hydrolase Lipoprotein Magnesium Membrane Metal-binding Methylation Nucleotide-binding Phosphoprotein Prenylation Protein transport Proteomics identification Reference proteome Transport |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9948485] Weiser, Joel, 2025-05-21 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | RAB4B |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8999713] ENSEMBL:ENSG00000167578 RAB4B [Homo sapiens] |
| secondaryIdentifier | RAB4B_HUMAN P22750 Q7Z514 Q9HBR6 |
| sequenceLength | 213 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:244648] UniProt:P61018-2 RAB4B [Homo sapiens] [ReferenceIsoform:404590] UniProt:P61018-1 RAB4B [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:6804976] RAB4B [secretory granule membrane] [Homo sapiens] [EntityWithAccessionedSequence:6804989] RAB4B [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:8873680] RAB4B [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:8874049] GGC-RAB4B [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:8875675] GGC-RAB4B [recycling endosome membrane] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:8874048] S-geranylgeranyl-L-cysteine at 213 [ModifiedResidue:8874050] S-geranylgeranyl-L-cysteine at 211 |
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No pathways have been reviewed or authored by UniProt:P61018 RAB4B (62800)
