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Details on Person UniProt:P61224 RAP1B
| Class:Id | ReferenceGeneProduct:62712 |
|---|---|
| _chainChangeLog | chain:1-181 added on Fri February 6 2015;propeptide:182-184 added on Fri February 6 2015 |
| _displayName | UniProt:P61224 RAP1B |
| _timestamp | 2025-02-21 19:42:15 |
| chain | chain:1-181 propeptide:182-184 |
| checksum | CE976895E5965224 |
| comment | FUNCTION GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Plays a role in the establishment of basal endothelial barrier function.CATALYTIC ACTIVITY GTP + H2O = GDP + phosphate + H(+)ACTIVITY REGULATION Activated by binding to the GTPase-activating protein RAP1GAP. Activated by guanine nucleotide-exchange factor (GEF) EPAC2 in a cAMP-dependent manner.SUBUNIT Heterodimer with RAP1GAP (PubMed:18309292). Interacts with EPAC2 (PubMed:18660803). Interacts with SGSM1 (PubMed:17509819). Interacts with SGSM2 (PubMed:17509819). Interacts with SGSM3 (PubMed:17509819). Interacts with KRIT1 (PubMed:22577140). Interacts with RAP1GDS1 (PubMed:24415755).INTERACTION May shuttle between plasma membrane and cytosol (PubMed:3141412). Presence of KRIT1 and CDH5 is required for its localization to the cell junction (PubMed:20332120).ALTERNATIVE PRODUCTS The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the small GTPase superfamily. Ras family. |
| description | recommendedName: Ras-related protein Rap-1b ecNumber evidence="2"3.6.5.2 alternativeName: GTP-binding protein smg p21B |
| geneName | RAP1B OK/SW-cl.11 |
| identifier | P61224 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure ADP-ribosylation Alternative splicing Cell junction Cell membrane Cytoplasm Direct protein sequencing Disease variant GTP-binding Hydrolase Lipoprotein Membrane Methylation Nucleotide-binding Phosphoprotein Prenylation Proteomics identification Reference proteome |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | RAP1B |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8950312] ENSEMBL:ENSG00000127314 RAP1B [Homo sapiens] |
| secondaryIdentifier | RAP1B_HUMAN B2R5Z2 B4DQI8 B4DW74 B4DW94 P09526 Q502X3 Q5TZR4 Q6DCA1 Q6LES0 |
| sequenceLength | 184 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8968495] UniProt:P61224-1 RAP1B [Homo sapiens] [ReferenceIsoform:8968496] UniProt:P61224-2 RAP1B [Homo sapiens] [ReferenceIsoform:8968497] UniProt:P61224-3 RAP1B [Homo sapiens] [ReferenceIsoform:8968498] UniProt:P61224-4 RAP1B [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:377590] RAP1B [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:6804972] RAP1B [azurophil granule membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P61224 RAP1B (62712)
