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Details on Person UniProt:P62834 RAP1A
| Class:Id | ReferenceGeneProduct:62704 |
|---|---|
| _chainChangeLog | chain:1-181 added on Fri February 6 2015;propeptide:182-184 added on Fri February 6 2015 |
| _displayName | UniProt:P62834 RAP1A |
| _timestamp | 2025-02-21 19:42:15 |
| chain | chain:1-181 propeptide:182-184 |
| checksum | 42C39290C98E0A92 |
| comment | FUNCTION Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localization to microtubules and membranes (PubMed:17916086). Plays a role in nerve growth factor (NGF)-induced neurite outgrowth. Plays a role in the regulation of embryonic blood vessel formation. Involved in the establishment of basal endothelial barrier function. Facilitates the progressive accumulation of CDH1 at mature desmosome junctions via cAMP-dependent signaling and its interaction with PKP3 (PubMed:25208567). May be involved in the regulation of the vascular endothelial growth factor receptor KDR expression at endothelial cell-cell junctions.CATALYTIC ACTIVITY GTP + H2O = GDP + phosphate + H(+)ACTIVITY REGULATION Activated by guanine nucleotide-exchange factors (GEF) EPAC and EPAC2 in a cAMP-dependent manner, and GFR.SUBUNIT Found in a complex, at least composed of ITGB1BP1, KRIT1 and RAP1A (PubMed:17916086). Interacts (active GTP-bound form preferentially) with KRIT1 (via C-terminus FERM domain); the interaction does not induce the opening conformation of KRIT1 (PubMed:17916086). Found in a complex composed of CDH1, RAP1A and PKP3; PKP3 acts as a scaffold protein within the complex, the complex is required for CDH1 localization to mature desmosome cell junctions (PubMed:25208567). In its GTP-bound form interacts with PLCE1 and RADIL (PubMed:11022048, PubMed:12444546, PubMed:17704304). Interacts with SGSM1, SGSM2 and SGSM3 (PubMed:17509819). Interacts (via GTP-bound active form) with RAPGEF2 (via Ras-associating domain) (PubMed:10608844, PubMed:11359771). Interacts with TBC1D21 (By similarity). Interacts with RAP1GDS1 (PubMed:20709748).INTERACTION Recruited from early endosome to late endosome compartment after nerve growth factor (NGF) stimulation. Localized with RAPGEF2 at cell-cell junctions (By similarity). Colocalized with RAPGEF2 in the perinuclear region.SIMILARITY Belongs to the small GTPase superfamily. Ras family. |
| description | recommendedName: Ras-related protein Rap-1A ecNumber evidence="2"3.6.5.2 alternativeName: C21KG alternativeName: G-22K alternativeName: GTP-binding protein smg p21A alternativeName: Ras-related protein Krev-1 |
| geneName | RAP1A KREV1 |
| identifier | P62834 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Cell junction Cell membrane Cytoplasm Direct protein sequencing Endosome GTP-binding Hydrolase Lipoprotein Membrane Methylation Neurogenesis Nucleotide-binding Prenylation Proteomics identification Reference proteome Tumor suppressor |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | RAP1A |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8962308] ENSEMBL:ENSG00000116473 RAP1A [Homo sapiens] |
| secondaryIdentifier | RAP1A_HUMAN P10113 |
| sequenceLength | 184 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:169884] RAP1A [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:190053] RAP1A [endosome membrane] [Homo sapiens] [EntityWithAccessionedSequence:354118] RAP1A [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:6806137] RAP1A [specific granule membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P62834 RAP1A (62704)
