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Details on Person UniProt:P55042 RRAD
| Class:Id | ReferenceGeneProduct:62666 |
|---|---|
| _chainChangeLog | chain:1-308 added on Fri February 6 2015 |
| _displayName | UniProt:P55042 RRAD |
| _timestamp | 2024-11-03 19:43:03 |
| chain | chain:1-308 |
| checksum | EF098960A371D2C4 |
| comment | FUNCTION May regulate basal voltage-dependent L-type Ca(2+) currents and be required for beta-adrenergic augmentation of Ca(2+) influx in cardiomyocytes, thereby regulating increases in heart rate and contractile force (By similarity). May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-gated L-type Ca(2+) currents (By similarity). Regulates voltage-dependent L-type calcium channel subunit alpha-1C trafficking to the cell membrane (By similarity). Inhibits cardiac hypertrophy through the calmodulin-dependent kinase II (CaMKII) pathway (PubMed:18056528). Inhibits phosphorylation and activation of CAMK2D (PubMed:18056528).SUBUNIT Interacts with calmodulin preferentially in the inactive, GDP-bound form (PubMed:18056528, PubMed:9115241). Binds CAMKII which is capable of phosphorylating RAD in vitro (PubMed:9115241). Interacts with CAMK2D (PubMed:18056528). Interacts with CACNB2; interaction may be involved in beta-adrenergic regulation of heart rate and contractile force (By similarity). Interaction with CACNB2 regulates the trafficking of CACNA1C to the cell membrane (By similarity).INTERACTION Most abundantly expressed in the heart. Also found in the skeletal muscle and lung. Lesser amounts in placenta and kidney. Also detected in adipose tissue. Overexpressed in muscle of type II diabetic humans.INDUCTION Down-regulated in failing hearts.SIMILARITY Belongs to the small GTPase superfamily. RGK family. |
| description | recommendedName: GTP-binding protein RAD alternativeName: RAD1 alternativeName: Ras associated with diabetes |
| geneName | RRAD RAD |
| identifier | P55042 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Calmodulin-binding Cell membrane GTP-binding Membrane Methylation Nucleotide-binding Phosphoprotein Proteomics identification Reference proteome |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | RRAD |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9000792] ENSEMBL:ENSG00000166592 RRAD [Homo sapiens] |
| secondaryIdentifier | RAD_HUMAN Q96F39 |
| sequenceLength | 308 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:9613158] RRAD [cytosol] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P55042 RRAD (62666)
