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Details on Person UniProt:O00194 RAB27B
| Class:Id | ReferenceGeneProduct:62600 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Sat February 7 2015;chain:2-218 added on Sat February 7 2015;initiator methionine:1 for 62600 removed on Fri Nov 03 2023;initiator methionine: for 62600 added on Fri Nov 03 2023;initiator methionine: for 62600 removed on Fri Aug 15 2025;initiator methionine:1 for 62600 added on Fri Aug 15 2025 |
| _displayName | UniProt:O00194 RAB27B |
| _timestamp | 2026-02-20 22:15:04 |
| chain | initiator methionine:1 chain:2-218 |
| checksum | 8ED640F0C15EDCD3 |
| comment | FUNCTION The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:21775604, PubMed:30771381). RAB27B regulates homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion (PubMed:30771381). Plays a role in NTRK2/TRKB axonal anterograde transport by facilitating the association of NTRK2/TRKB with KLC1 (PubMed:21775604). May be involved in targeting uroplakins to urothelial apical membranes (By similarity).CATALYTIC ACTIVITY GTP + H2O = GDP + phosphate + H(+)COFACTOR Regulated by guanine nucleotide exchange factors (GEFs) including DENND10, which promote the exchange of bound GDP for free GTP (Probable). Regulated by GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity. Inhibited by GDP dissociation inhibitors (GDIs) (Probable).SUBUNIT Interacts with SYTL2, SYTL4, MYRIP and MLPH. Interacts with RPH3A and RPH3A (By similarity). Interacts (GDP-bound form preferentially) with DENND10 (PubMed:30771381).INTERACTION Expressed primarily in testis.DOMAIN Switch I, switch II and the interswitch regions are characteristic of Rab GTPases and mediate the interactions with Rab downstream effectors. The switch regions undergo conformational changes upon nucleotide binding which drive interaction with specific sets of effector proteins, with most effectors only binding to GTP-bound Rab.SIMILARITY Belongs to the small GTPase superfamily. Rab family. |
| description | recommendedName: Ras-related protein Rab-27B ecNumber evidence="12"3.6.5.2 alternativeName: C25KG |
| geneName | RAB27B |
| identifier | O00194 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Direct protein sequencing Disulfide bond Endosome GTP-binding Hydrolase Lipoprotein Magnesium Membrane Metal-binding Methylation Nucleotide-binding Prenylation Proteomics identification Reference proteome |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | RAB27B |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9001389] ENSEMBL:ENSG00000041353 RAB27B [Homo sapiens] |
| secondaryIdentifier | RB27B_HUMAN B2RAB0 Q9BZB6 |
| sequenceLength | 218 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:8862952] RAB27B [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:8862955] RAB27B [platelet dense granule membrane] [Homo sapiens] [EntityWithAccessionedSequence:8873706] RAB27B [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:8873786] GGC-RAB27B [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:8877280] GGC-RAB27B [melanosome membrane] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:8873760] S-geranylgeranyl-L-cysteine at 216 [ModifiedResidue:8873761] S-geranylgeranyl-L-cysteine at 218 |
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No pathways have been reviewed or authored by UniProt:O00194 RAB27B (62600)
