Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:P62491 RAB11A
| Class:Id | ReferenceGeneProduct:62567 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Sat February 7 2015;chain:2-213 added on Sat February 7 2015;propeptide:214-216 added on Sat February 7 2015;initiator methionine:1 for 62567 removed on Fri Nov 03 2023;initiator methionine: for 62567 added on Fri Nov 03 2023;initiator methionine: for 62567 removed on Fri Aug 15 2025;initiator methionine:1 for 62567 added on Fri Aug 15 2025 |
| _displayName | UniProt:P62491 RAB11A |
| _timestamp | 2026-02-20 22:48:10 |
| chain | initiator methionine:1 chain:2-213 propeptide:214-216 |
| checksum | 76FC1E113A29B269 |
| comment | FUNCTION The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:15601896, PubMed:15689490, PubMed:17462998, PubMed:19542231, PubMed:20026645, PubMed:20890297, PubMed:21282656, PubMed:26032412). RAB11A regulates endocytic recycling (PubMed:20026645). Forms a functional Rab11/RAB11FIP3/dynein complex that regulates the movement of peripheral sorting endosomes (SE) along microtubule tracks toward the microtubule organizing center/centrosome, generating the endosomal recycling compartment (ERC) (PubMed:20026645). Acts as a major regulator of membrane delivery during cytokinesis (PubMed:15601896). Together with MYO5B and RAB8A participates in epithelial cell polarization (PubMed:21282656). Together with Rabin8/RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis (PubMed:20890297). Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells (PubMed:17462998). Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane (PubMed:19542231). Participates in the sorting and basolateral transport of CDH1 from the Golgi apparatus to the plasma membrane (PubMed:15689490). Regulates the recycling of FCGRT (receptor of Fc region of monomeric IgG) to basolateral membranes (By similarity). May also play a role in melanosome transport and release from melanocytes (By similarity). Promotes Rabin8/RAB3IP preciliary vesicular trafficking to mother centriole by forming a ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, thereby regulating ciliogenesis initiation (PubMed:25673879, PubMed:31204173). On the contrary, upon LPAR1 receptor signaling pathway activation, interaction with phosphorylated WDR44 prevents Rab11-RAB3IP-RAB11FIP3 complex formation and cilia growth (PubMed:31204173). Participates in the export of a subset of neosynthesized proteins through a Rab8-Rab10-Rab11-endososomal dependent export route via interaction with WDR44 (PubMed:32344433). Also interacts with RABL3 to promote ciliary vesicle formation (PubMed:36052645).CATALYTIC ACTIVITY GTP + H2O = GDP + phosphate + H(+)COFACTOR Regulated by guanine nucleotide exchange factors (GEFs) including SH3BP5, which promote the exchange of bound GDP for free GTP (PubMed:30217979). Regulated by GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity (Probable). Inhibited by GDP dissociation inhibitors (GDIs) which prevent Rab-GDP dissociation (Probable).SUBUNIT Interacts (GTP-bound form) with RAB11FIPs (via their C-termini) including RAB11FIP1, RAB11FIP2, RAB11FIP3, RAB11FIP4 and RAB11FIP5 effectors (PubMed:11495908, PubMed:11786538, PubMed:12470645, PubMed:15173169, PubMed:15181150, PubMed:15280022, PubMed:15601896, PubMed:16148947, PubMed:16905101, PubMed:17030804, PubMed:17229837, PubMed:20026645, PubMed:25673879, PubMed:26032412, PubMed:26258637, PubMed:31204173). Interacts with RAB11FIP5 and STXBP6. Interacts with SGSM1, SGSM2 and SGSM3 (By similarity). Interacts with EXOC6 in a GTP-dependent manner (By similarity). Forms a complex with RAB11FIP3 and dynein intermediate chain DYNC1LI1; the interaction between RAB11A1 and RAB11FIP3 is direct; the complex regulates endocytic trafficking (PubMed:20026645). Interacts with EVI5; EVI5 and RAB11FIP3 may be mutually exclusive and compete for binding RAB11A (By similarity). Interacts with STXBP6 (By similarity). Interacts with VIPAS39. Interacts with MYO5B. Found in a complex with MYO5B and CFTR. Interacts with NPC1L1. Interacts (GDP-bound form) with ZFYVE27 (PubMed:17082457, PubMed:21976701). Interacts with BIRC6/bruce. May interact with TBC1D14. Interacts with UNC119; in a cell cycle-dependent manner. GDP-bound and nucleotide-free forms interact with SH3BP5 (PubMed:26506309, PubMed:30217979). Interacts (GDP-bound form) with KIF5A in a ZFYVE27-dependent manner (PubMed:21976701). Interacts (GDP-bound form) with RELCH (By similarity). Found in a complex composed of RELCH, OSBP1 and RAB11A (By similarity). Interacts with TBC1D12 (PubMed:28384198). Interacts with DEF6 (PubMed:31308374). Interacts with VPS33B (PubMed:28017832). Interacts with ATP9A (PubMed:36604604). Forms a heterotetramer with RAB11FIP3; the GTP-bound form is preferred for binding (PubMed:26258637). Forms a complex with Rabin8/RAB3IP and RAB11FIP3, probably a heterohexamer with two of each protein subunit, where Rabin8/RAB3IP and RAB11FIP3 simultaneously bind to RAB11A; the complex promotes preciliary trafficking and cilia growth (PubMed:26258637, PubMed:31204173). Forms a complex containing RAB11A, ASAP1, Rabin8/RAB3IP, RAP11FIP3 and ARF4; the complex promotes preciliary trafficking; the complex binds to RHO in photoreceptor cells and promotes RHO ciliary transport (PubMed:25673879, PubMed:26258637). Interacts (GTP-bound form) with WDR44; the interaction prevents RAB11A-RAB3IP-RAB11FIP3 complex formation (PubMed:10077598, PubMed:31204173, PubMed:32344433). Interacts with SH3TC2 (PubMed:20028792). Interacts (GTP-bound) with RABL3 (GDP-bound); the interaction stabilizes RABL3 and regulates ciliary vesicle formation during early ciliogenesis (PubMed:36052645).INTERACTION Localized to WDR44-positive endosomes and tubules (PubMed:32344433). Translocates with RAB11FIP2 from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane (PubMed:11994279). During interphase, localized in vesicles continuously moving from peripheral sorting endosomes towards the pericentrosomal ERC (PubMed:20026645). Localizes to the cleavage furrow (PubMed:15601896). Colocalizes with PARD3, PRKCI, EXOC5, OCLN, PODXL and RAB8A in apical membrane initiation sites (AMIS) during the generation of apical surface and lumenogenesis (PubMed:20890297). Recruited to phagosomes containing S.aureus or M.tuberculosis (PubMed:21255211). Localized to rhodopsin transport carriers when interacting with RAB11AFIP3 and ASAP1 in photoreceptors (PubMed:25673879). Colocalizes with RAB11AFIP1 on punctate vesicles (PubMed:26032412).ALTERNATIVE PRODUCTS Switch I, switch II and the interswitch regions are characteristic of Rab GTPases and mediate the interactions with Rab downstream effectors. The switch regions undergo conformational changes upon nucleotide binding which drives interaction with specific sets of effector proteins, with most effectors only binding to GTP-bound Rab.PTM (Microbial infection) Glycosylated on arginine residues by S.typhimurium protein Ssek3.SIMILARITY Belongs to the small GTPase superfamily. Rab family. |
| description | recommendedName: fullName evidence="59"Ras-related protein Rab-11A shortName evidence="59"Rab-11 ecNumber evidence="4"3.6.5.2 alternativeName: YL8 |
| geneName | RAB11A RAB11 |
| identifier | P62491 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing Cell cycle Cell membrane Cell projection Cytoplasmic vesicle Direct protein sequencing Endosome Glycoprotein Golgi apparatus GTP-binding Hydrolase Lipoprotein Membrane Methylation Nucleotide-binding Prenylation Protein transport Proteomics identification Reference proteome Transport |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9841277] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9909836] Weiser, Joel, 2024-05-14 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9948485] Weiser, Joel, 2025-05-21 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | RAB11A |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8996210] ENSEMBL:ENSG00000103769 RAB11A [Homo sapiens] |
| secondaryIdentifier | RB11A_HUMAN B2R4B6 B4DT13 P24410 Q5TZN9 Q9JLX1 |
| sequenceLength | 216 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8968021] UniProt:P62491-1 RAB11A [Homo sapiens] [ReferenceIsoform:8968022] UniProt:P62491-2 RAB11A [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:1458519] GGC-RAB11A [cytoplasmic vesicle membrane] [Homo sapiens] [EntityWithAccessionedSequence:2029008] RAB11A [phagocytic vesicle membrane] [Homo sapiens] [EntityWithAccessionedSequence:2029023] RAB11A [recycling endosome membrane] [Homo sapiens] [EntityWithAccessionedSequence:5623395] RAB11A [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:8873781] GGC-RAB11A [cytosol] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:8873738] S-geranylgeranyl-L-cysteine at 213 [ModifiedResidue:8873744] S-geranylgeranyl-L-cysteine at 212 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P62491 RAB11A (62567)
