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Details on Person UniProt:P11498 PC
| Class:Id | ReferenceGeneProduct:62537 |
|---|---|
| _chainChangeLog | transit peptide:1-20 added on Sat February 7 2015;chain:21-1178 added on Sat February 7 2015 |
| _displayName | UniProt:P11498 PC |
| _timestamp | 2025-02-21 19:00:47 |
| chain | transit peptide:1-20 chain:21-1178 |
| checksum | 381F527553A20095 |
| comment | FUNCTION Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate.CATALYTIC ACTIVITY hydrogencarbonate + pyruvate + ATP = oxaloacetate + ADP + phosphate + H(+)COFACTOR Binds 1 Mn(2+) ion per subunit.PATHWAY Carbohydrate biosynthesis; gluconeogenesis.SUBUNIT Homotetramer (PubMed:18297087). Interacts (via the biotin carboxylation domain) with SIRT4 (PubMed:23438705).INTERACTION Acetylation of Lys-748 might play a role in catalytic activity regulation.DISEASE The disease is caused by variants affecting the gene represented in this entry.ONLINE INFORMATION Pyruvate carboxylase entry |
| description | recommendedName: fullName evidence="16"Pyruvate carboxylase, mitochondrial ecNumber evidence="13"6.4.1.1 alternativeName: Pyruvic carboxylase shortName: PCB |
| geneName | PC |
| identifier | P11498 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing ATP-binding Biotin Disease variant Gluconeogenesis Ligase Lipid biosynthesis Lipid metabolism Manganese Metal-binding Mitochondrion Multifunctional enzyme Nucleotide-binding Phosphoprotein Proteomics identification Pyruvate Reference proteome Transit peptide |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | PC |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8993256] ENSEMBL:ENSG00000173599 PC [Homo sapiens] |
| secondaryIdentifier | PYC_HUMAN B4DN00 Q16705 |
| sequenceLength | 1178 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8977163] UniProt:P11498-1 PC [Homo sapiens] [ReferenceIsoform:8977164] UniProt:P11498-2 PC [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:2993804] Btn-PC [mitochondrial matrix] [Homo sapiens] [EntityWithAccessionedSequence:3323119] PC [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:3323170] Btn-PC [cytosol] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:2993806] N6-biotinyl-L-lysine at 1144 |
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No pathways have been reviewed or authored by UniProt:P11498 PC (62537)
